Evidence map›Paper›PMID 23764678›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013

Systematic review of natural agents for the management of oral mucositis in cancer patients.

Noam Yarom, Anura Ariyawardana, Allan Hovan, Andrei Barasch, Virginia Jarvis, Siri Beier Jensen, Yehuda Zadik, Sharon Elad, Joanne Bowen, Rajesh V Lalla and 1 more

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05308732 (Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy), which is not on this map. Cited by 38 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 8 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05308732 phase1active not recruitingnot on this mapstarted 2021, after this paper: background citation

Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2021 to 2026Enrolled20ConditionsHead and Neck Neoplasms, Mucositis Oral, Radiotherapy, ComplicationsArmsCopaiba
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 8 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Pooled it
  7. Guideline
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Review
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  17. Review
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  19. Article
  20. Oral mucositis: the hidden side of cancer therapy.Journal of experimental & clinical cancer research : CR · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 5 countries.

Noam YaromDepartment of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer, Israel, noamyar@post.tau.ac.il.
Anura Ariyawardana
Allan Hovan
Andrei Barasch
Virginia Jarvis
Siri Beier Jensen
Yehuda Zadik
Sharon Elad
Joanne Bowen
Rajesh V Lalla
Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
BC Cancer Agency · CAEastman Chemical Company (United States) · USGriffith University · AUIsrael Defense Forces Medical Corps · ILOttawa Hospital · CATel Aviv University · ILUConn Health · USUniversity of Adelaide · AUUniversity of Copenhagen · DKWinthrop-University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to review the available literature and define clinical practice guidelines for the use of natural agents for the prevention and treatment of oral mucositis.

methodsA systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible.

resultsA total of 49 papers across 15 interventions were examined. A new suggestion was developed in favor of systemic zinc supplements administered orally in the prevention of oral mucositis in oral cancer patients receiving radiation therapy or chemoradiation (Level III evidence). A recommendation was made against the use of intravenous glutamine for the prevention of oral mucositis in patients receiving high-dose chemotherapy prior to hematopoietic stem cell transplant (Level II evidence). No guideline was possible for any other agent, due to inadequate and/or conflicting evidence.

conclusionsOf the various natural agents reviewed here, the available evidence supported a guideline only for two agents: a suggestion in favor of zinc and a recommendation against glutamine, in the treatment settings listed above. Well-designed studies of other natural agents are warranted.

Indexed as

ChemoradiotherapyGlutamineHead and Neck NeoplasmsHoneyHumansPractice Guidelines as TopicStomatitisTrace ElementsVitaminsZincGlutamineTrace ElementsVitaminsZinc

Identifiers

PMID23764678
OpenAlexW1972275625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.