Evidence map›Paper›PMID 23764641›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Cross-sectional HIV incidence estimation in HIV prevention research.

Ron Brookmeyer, Oliver Laeyendecker, Deborah Donnell, Susan H Eshleman

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
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  4. Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT.Journal of acquired immune deficiency syndromes (1999) · 2017
    Trial
  5. Trial
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  7. Study design approaches for future active-controlled HIV prevention trials.Statistical communications in infectious diseases · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Modeling methods for estimating HIV incidence: a mathematical review.Theoretical biology & medical modelling · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Cross-Sectional HIV Incidence Estimation with Missing Biomarkers.Statistical communications in infectious diseases · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Ron BrookmeyerDepartment of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Oliver Laeyendecker
Deborah Donnell
Susan H Eshleman
Infectious Disease Research Institute · USJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of California, Los Angeles · US

Funding

SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Laboratory and Statistical Development of Cross-Sectional HIV Incidence AssaysR01AI095068 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ESHLEMAN, SUSAN H · 2011 to 2021
$6.6M
Intramural NIH HHS ZIA AI000361NIAID NIH HHS R01 AI095068NIAID NIH HHS R01-AI095068NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1-AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1-AI068617
6 · The paper itself

Abstract

Accurate methods for estimating HIV incidence from cross-sectional samples would have great utility in prevention research. This report describes recent improvements in cross-sectional methods that significantly improve their accuracy. These improvements are based on the use of multiple biomarkers to identify recent HIV infections. These multiassay algorithms (MAAs) use assays in a hierarchical approach for testing that minimizes the effort and cost of incidence estimation. These MAAs do not require mathematical adjustments for accurate estimation of the incidence rates in study populations in the year before sample collection. MAAs provide a practical, accurate, and cost-effective approach for cross-sectional HIV incidence estimation that can be used for HIV prevention research and global epidemic monitoring.

Indexed as

Models, StatisticalResearch DesignAlgorithmsBiomarkersCase-Control StudiesCross-Sectional StudiesHIV InfectionsHIV SeropositivityHumansImmunoenzyme TechniquesIncidenceLimit of DetectionPrevalenceRandomized Controlled Trials as TopicReproducibility of ResultsRisk FactorsBiomarkers

Identifiers

PMID23764641
PMCPMC3737594
OpenAlexW2062377576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.