Trial reportJournal of acquired immune deficiency syndromes (1999)2013
Can combination prevention strategies reduce HIV transmission in generalized epidemic settings in Africa? The HPTN 071 (PopART) study plan in South Africa and Zambia.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01900977 (Population Effects of Antiretroviral Therapy to Reduce HIV Transmission), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Population Effects of Antiretroviral Therapy to Reduce HIV Transmission (PopART): A Cluster-randomized Trial of the Impact of a Combination Prevention Package on Population-level HIV Incidence in Zambia and South Africa
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A Review of Network Models for HIV Spread.Journal of acquired immune deficiency syndromes (1999) · 2025Pooled it
- Structural and community-level interventions for increasing condom use to prevent the transmission of HIV and other sexually transmitted infections.The Cochrane database of systematic reviews · 2014Pooled it
- The Spear and Shield intervention to increase the availability and acceptability of voluntary medical male circumcision in Zambia: a cluster randomised controlled trial.The lancet. HIV · 2015Trial
- Trial
- Keep It Up! 3.0: Study protocol for a type III hybrid implementation-effectiveness cluster-randomized trial.Contemporary clinical trials · 2023Article
- Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Costing the implementation of public health interventions in resource-limited settings: a conceptual framework.Implementation science : IS · 2020Article
- Assessing the feasibility of a life history calendar to measure HIV risk and health in older South Africans.PloS one · 2020Article
- Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors.BMC medicine · 2019Article
- Assessing Individual and Disseminated Effects in Network-Randomized Studies.American journal of epidemiology · 2018Article
- Shifting the HIV Paradigm from Care to Cure: Proceedings from the Caribbean Expert Summit in Barbados, August 2017.AIDS research and human retroviruses · 2018Article
- Consensus statement: Supporting Safer Conception and Pregnancy For Men And Women Living with and Affected by HIV.AIDS and behavior · 2018Article
- The impact of a therapeutic exercise intervention on depression and body self-image in HIV-positive women in sub-Saharan Africa.HIV/AIDS (Auckland, N.Z.) · 2018Article
- "I was referred from the other side": Gender and HIV testing among older South Africans living with HIV.PloS one · 2018Article
- Who Needs to Be Targeted for HIV Testing and Treatment in KwaZulu-Natal? Results From a Population-Based Survey.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Good Health and Moral Responsibility: Key Concepts Underlying the Interpretation of Treatment as Prevention in South Africa and Zambia Before Rolling Out Universal HIV Testing and Treatment.AIDS patient care and STDs · 2016Article
- HIV Self-Testing: a Review of Current Implementation and Fidelity.Current HIV/AIDS reports · 2016Review
- HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities.The open AIDS journal · 2016Article
- A composite likelihood approach for estimating HIV prevalence in the presence of spatial variation.Statistics in medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The HIV Prevention Trials Network (HPTN) is conducting the HPTN 071 (PopART) study in 21 communities in Zambia and South Africa with support from a consortium of funders. HPTN 071 (PopART) is a community-randomized trial of a combination prevention strategy to reduce HIV incidence in the context of the generalized epidemic of southern Africa. The full PopART intervention strategy is anchored in home-based HIV testing and facilitated linkage of HIV-infected persons to care through community health workers and universal antiretroviral therapy for seropositive persons regardless of CD4+ cell count or HIV viral load. To further reduce the risk of HIV acquisition among uninfected individuals, the study aims to expand voluntary medical male circumcision, diagnosis and treatment of sexually transmitted infections, behavioral counseling, and condom distribution. The full PopART intervention strategy also incorporates promotion of other interventions designed to reduce HIV and tuberculosis transmission, including optimization of the prevention of mother-to-child HIV transmission and enhanced individual and public health tuberculosis services. Success for the PopART strategy depends on the ability to increase coverage for the study interventions whose uptake is a necessary antecedent to a prevention effect. Processes will be measured to assess the degree of penetration of the interventions into the communities. A randomly sampled population cohort from each community will be used to measure the impact of the PopART strategy on HIV incidence over 3 years. We describe the strategy being tested and progress to date in the HPTN 071 (PopART) study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.