Evidence map›Paper›PMID 23764630›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Overcoming biological, behavioral, and structural vulnerabilities: new directions in research to decrease HIV transmission in men who have sex with men.

Kenneth H Mayer, Darrell P Wheeler, Linda-Gail Bekker, Beatriz Grinsztejn, Robert H Remien, Theodorus G M Sandfort, Chris Beyrer

Registry-linked trialAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02611362 (A Multilevel Gaming Intervention for Persons on PrEP), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02611362 nacompletednot on this mapstarted 2015, after this paper: background citation

A Multilevel Gaming Intervention for Persons on PrEP

TypeinterventionalSponsorRhode Island HospitalRan2015 to 2019Enrolled82ConditionsMSM, PrEP, HIV RiskArmsIMB Gaming Intervention
3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Stigma Diminishes the Protective Effect of Social Support on Psychological Distress Among Young Black Men Who Have Sex With Men.AIDS education and prevention : official publication of the International Society for AIDS Education · 2018
    Trial
  2. Trial
  3. Article
  4. Risk factors for sexually transmitted infections among men who have sex with men.African journal of primary health care & family medicine · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenneth H MayerBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. kmayer@fenwayhealth.org
Darrell P Wheeler
Linda-Gail Bekker
Beatriz Grinsztejn
Robert H Remien
Theodorus G M Sandfort
Chris Beyrer

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
Harvard Medical School Vaccine Clinical Trials UnitUM1AI069412 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Lindsey Robert Baden, Daniel R. Kuritzkes · 2012 to 2026
$57.2M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILTON L WAINBERG · 2003 to 2026
$48.2M
Clinical Trial Unit for HIV Prevention and Microbicide ResearchUM1AI069480 · NIAID · FENWAY COMMUNITY HEALTH CENTER · PI MAYER, KENNETH H · 2012 to 2014
$2.3M
NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI069412NIAID NIH HHS UM1 AI069480NIMH NIH HHS P30 MH043520
6 · The paper itself

Abstract

Men who have sex with men (MSM), including transgender women, comprise a heterogeneous group of individuals whose sexual behaviors and gender identities may vary widely between cultures and among individuals. Their sources of increased vulnerability to HIV are diverse, including the increased efficiency of HIV transmission via unprotected anal intercourse, sexual role versatility, asymptomatic sexually transmitted infections, and behavioral factors that may be associated with condomless sex with multiple partners. Societal stigmatization of homosexual behavior and gender nonconformity may result in internalized negative feelings that lead to depression, other affective disorders, and substance use, which in turn are associated with increased risk-taking behaviors. Social stigma and punitive civil environments may lead to delays in seeking HIV and sexually transmitted disease screening, and later initiation of antiretroviral therapy. The iPrEX study demonstrated that chemoprophylaxis can decrease HIV acquisition in MSM, and the HIV prevention trials network 052 study established the biological plausibility that earlier initiation of highly active antiretroviral therapy can decrease HIV transmission to uninfected partners. Despite these advances, MSM remain among the most significantly HIV-affected population in resource-rich and limited settings. New studies will integrate enhanced understanding of the biology of enhanced rectal transmission of HIV and the focused use of antiretrovirals for prevention with culturally tailored approaches that address the potentiating social and behavioral factors associated with enhanced HIV spread among MSM.

Indexed as

Sexual BehaviorAdolescentAdultAffective Disorders, PsychoticAfricaAnti-Retroviral AgentsAsiaDepressionFemaleGender IdentityHIV InfectionsHomosexuality, MaleHumansLatin AmericaMaleMiddle AgedAnti-Retroviral Agents

Identifiers

PMID23764630
PMCPMC3740716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.