ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2013
Incidence and predictors of severe anemia in Asian HIV-infected children using first-line antiretroviral therapy.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Predictors of anemia among HIV-infected children in Ethiopia: systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Incidence and predictors of anemia among children with antiretroviral therapy at health facilities in Southern Ethiopia: A retrospective follow-up study.SAGE open medicine · 2025Article
- Magnitude of anemia and associated factors among HIV infected children on antiretroviral therapy in Awi zone health facilities, Northwest Ethiopia, 2023.BMC infectious diseases · 2024Article
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- Maraviroc Population Pharmacokinetics Within the First 6 Weeks of Life.The Pediatric infectious disease journal · 2022Article
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- Anemia among children living with HIV/AIDS on HAART in Mekelle Hospital, Tigray regional state of northern ethiopia - a cross-sectional study.BMC pediatrics · 2021Article
- Article
- Article
- Machine-learning classification of neurocognitive performance in children with perinatal HIV initiating de novo antiretroviral therapy.AIDS (London, England) · 2020Article
- Incidence and Predictors of Anemia Among Children on Antiretroviral Therapy at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2007-2017: A Retrospective Follow-Up Study.HIV/AIDS (Auckland, N.Z.) · 2020Article
- Anemia and Related Factors Among Highly Active Antiretroviral Therapy Experienced Children in Hawassa Comprehensive Specialized Hospital, Southern Ethiopia: Emphasis on Patient Management.Drug, healthcare and patient safety · 2020Article
- Prevalence and risk factors of anaemia in hospitalised HIV-infected patients in southeast China: a retrospective study.Epidemiology and infection · 2019Article
- Hematologic abnormalities and associated factors among HIV infected children pre- and post-antiretroviral treatment, North West Ethiopia.Journal of blood medicine · 2017Article
- HIV-infected children in the Asia-Pacific region with baseline severe anemia: antiretroviral therapy and outcomes.Asian biomedicine : research, reviews and news · 2016Article
- Anemia, diet and therapeutic iron among children living with HIV: a prospective cohort study.BMC pediatrics · 2015Article
- Serious adverse events are uncommon with combination neonatal antiretroviral prophylaxis: a retrospective case review.PloS one · 2015Article
- To study the incidence of anemia in HIV-infected children on zidovudine-based highly active antiretroviral therapy regimen.Indian journal of sexually transmitted diseases and AIDSArticle
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19 authors at 14 institutions in 8 countries.
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Abstract
backgroundThere are limited data on treatment-related anemia in Asian HIV-infected children.
methodsData from Asian HIV-infected children aged <18 years on first-line highly active antiretroviral therapy (HAART) were used. Children who had pre-existing severe anemia at baseline were excluded. Anemia was graded using the United States Division of AIDS (DAIDS) 2004 table. Potential risk factors for severe anemia were assessed by logistic regression.
resultsData from 1648 children (51.9% female, 62.8% World Health Organization (WHO) stage 3/4) were analyzed. Median (interquartile range) age was 6.8 (3.7-9.6) years, CD4% was 9 (3-16)%, and plasma HIV-RNA was 5.2 (4.7-5.6) log10 copies/ml at HAART initiation in those with available testing. The most common regimens were stavudine/lamivudine/nevirapine (42%) and zidovudine/lamivudine/nevirapine (25%). Severe anemia was identified in 47 (2.9%) children after a median time of 6 months after HAART initiation, with an incidence rate of 5.4 per 100 child-years. Mild anemia or moderate anemia at baseline (p = 0.024 and p = 0.005, respectively), previous or current use of zidovudine (p < 0.0001 and p = 0.013, respectively), and male sex (p = 0.008) were associated with severe anemia. Higher weight-for-age z-score (p = 0.004) was protective.
conclusionsThe incidence of severe anemia in Asian HIV-infected children after HAART initiation was low and mainly occurred during the first few months after HAART initiation. Mild to moderate anemia at baseline and using zidovudine were independent risk factors for the development of severe anemia.
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