ArticleNeurotoxicology2013
Urinary delta-ALA: a potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, arsenic and manganese.
Article in Neurotoxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework.Risk analysis : an official publication of the Society for Risk Analysis · 2015Pooled it
- Societal-level Risk Factors Associated with Pediatric Hearing Loss: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2014Pooled it
- Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases.International journal of nanomedicine · 2023Review
- Metabolic and genetic derangement: a review of mechanisms involved in arsenic and lead toxicity and genotoxicity.Arhiv za higijenu rada i toksikologiju · 2022Review
- Assessment of potters' occupational exposure to lead and associated risk factors in Maragogipinho, Brazil: preliminary results.International archives of occupational and environmental health · 2021Article
- Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture.Arhiv za higijenu rada i toksikologiju · 2020Article
- Assessment of potential human health risk of trace element in wild edible mushroom species collected from Yunnan Province, China.Environmental science and pollution research international · 2020Article
- Metal environmental contamination within different human exposure context- specific and non-specific biomarkers.Toxicology letters · 2020Article
- Metal-induced nephrotoxicity to diabetic and non-diabetic Wistar rats.Environmental science and pollution research international · 2019Article
- Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos.Toxicology reports · 2019Article
- Assessment of Lead Exposure and Urinary-δ-aminolevulinic Acid Levels in Male Lead Acid Battery Workers in Tamil Nadu, India.Journal of health & pollution · 2018Article
- The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics?International journal of environmental research and public health · 2017Review
- Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.EC pharmacology and toxicology · 2017Article
- Arsenic and manganese alter lead deposition in the rat.Biological trace element research · 2014Article
- Chemical mixtures and children's health.Current opinion in pediatrics · 2014Review
- Defects in base excision repair sensitize cells to manganese in S. cerevisiae.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Lead (Pb), arsenic (As) and manganese (Mn) are neurotoxic elements that often occur in mixtures for which practically no information is available on biomarkers (BMs) for the evaluation of exposure/effects. Exposures to these metals may increase delta-aminolevulinic acid (delta-ALA), which in itself may potentiate neurotoxicity. The objective of this study was to investigate the utility of urinary delta-ALA (delta-ALA-U) levels as BM of exposure and/or neurotoxic effects induced by this mixture. Five groups of Wistar rats were treated for 8 days with Pb (5mg/kg), As (60mg/L), Mn (10mg/kg), the 3-metal mixture (same doses of the single metals), and control group. Motor activity was evaluated and 24-h urine collected before and after the treatment. 24-hours (h) after the last dose, the rats were sacrificed and the brains removed for analyses. Delta-ALA and metal levels were determined in brain and urine. Co-treated rats showed a significant (p<0.05) correlation between increased Pb, As, Mn and delta-ALA levels in the brain and decreased motor activity. Delta-ALA-U concentrations were higher in the mixture-treated group than the sum of the delta-ALA-U levels in each single-treated groups and discriminated (p<0.05) between the mixture and untreated rats. Moreover, delta-ALA-U was correlated (p<0.05) with brain delta-ALA levels. These results establish that treatments with this metal mixture exacerbate behavioral dysfunction, increasing most prominently brain Pb levels. This study is the first to establish that delta-ALA-U levels represent a sensitive BM of exposure/neurotoxic effect to this metal mixture.
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Registered trials
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