ArticleNeuron2013
Directional hearing by linear summation of binaural inputs at the medial superior olive.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Spiking Neural Network Models of Interaural Time Difference Extraction via a Massively Collaborative Process.eNeuro · 2025Article
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Developmental fine-tuning of medial superior olive neurons mitigates their predisposition to contralateral sound sources.PLoS biology · 2024Article
- Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.Frontiers in neuroscience · 2022Article
- Dendritic synapse geometry optimizes binaural computation in a sound localization circuit.Science advances · 2021Article
- Arrangement of Excitatory Synaptic Inputs on Dendrites of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Characterization of Developmental Changes in Spontaneous Electrical Activity of Medial Superior Olivary Neurons Before Hearing Onset With a Combination of Injectable and Volatile Anesthesia.Frontiers in neuroscience · 2021Article
- Specific loss of neural sensitivity to interaural time difference of unmodulated noise stimuli following noise-induced hearing loss.Journal of neurophysiology · 2020Article
- Soma-axon coupling configurations that enhance neuronal coincidence detection.PLoS computational biology · 2019Article
- Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection.PLoS computational biology · 2018Article
- The Calyx of Held: A Hypothesis on the Need for Reliable Timing in an Intensity-Difference Encoder.Neuron · 2018Review
- Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.The Journal of physiology · 2018Article
- Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem.Nature communications · 2018Article
- Subcortical pathways: Towards a better understanding of auditory disorders.Hearing research · 2018Review
- Article
- Contribution of action potentials to the extracellular field potential in the nucleus laminaris of barn owl.Journal of neurophysiology · 2018Article
- Signatures of Somatic Inhibition and Dendritic Excitation in Auditory Brainstem Field Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Enhancement of phase-locking in rodents. I. An axonal recording study in gerbil.Journal of neurophysiology · 2017Article
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6 authors.
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Abstract
Neurons in the medial superior olive (MSO) enable sound localization by their remarkable sensitivity to submillisecond interaural time differences (ITDs). Each MSO neuron has its own "best ITD" to which it responds optimally. A difference in physical path length of the excitatory inputs from both ears cannot fully account for the ITD tuning of MSO neurons. As a result, it is still debated how these inputs interact and whether the segregation of inputs to opposite dendrites, well-timed synaptic inhibition, or asymmetries in synaptic potentials or cellular morphology further optimize coincidence detection or ITD tuning. Using in vivo whole-cell and juxtacellular recordings, we show here that ITD tuning of MSO neurons is determined by the timing of their excitatory inputs. The inputs from both ears sum linearly, whereas spike probability depends nonlinearly on the size of synaptic inputs. This simple coincidence detection scheme thus makes accurate sound localization possible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.