ArticleNeuron2013
A mechanistic understanding of the role of feedforward inhibition in the mammalian sound localization circuitry.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed, 107 citations in OpenAlex.
- Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.The Journal of comparative neurology · 2026Article
- Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026Article
- Spiking Neural Network Models of Interaural Time Difference Extraction via a Massively Collaborative Process.eNeuro · 2025Article
- A mammalian inferior colliculus model for sound source separation using interaural time differences.PLoS computational biology · 2025Article
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- Distinct cell classes in the superior paraolivary nucleus (SPN) region in the gerbil auditory brainstem revealed by in vivo physiological and anatomical characterization.Hearing research · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmental fine-tuning of medial superior olive neurons mitigates their predisposition to contralateral sound sources.PLoS biology · 2024Article
- Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris.Biological cybernetics · 2023Article
- Article
- Review
- Binaural Processing Deficits Due to Synaptopathy and Myelin Defects.Frontiers in neural circuits · 2022Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.Frontiers in neuroscience · 2022Article
- Specific loss of neural sensitivity to interaural time difference of unmodulated noise stimuli following noise-induced hearing loss.Journal of neurophysiology · 2020Article
- In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity.Journal of visualized experiments : JoVE · 2020Article
- Synaptic Inhibition of Medial Olivocochlear Efferent Neurons by Neurons of the Medial Nucleus of the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice.eLife · 2019Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Feedforward inhibition sharpens the precision of neurons throughout ascending auditory pathways, including the binaural neurons of the medial superior olive (MSO). However, the biophysical influence of inhibition is poorly understood, particularly at higher frequencies at which the relative phase of inhibition and excitation becomes ambiguous. Here, we show in gerbil MSO principal cells in vitro that feedforward inhibition precedes direct excitation, providing a concurrent hyperpolarization and conductance shunt during EPSP summation. We show with dual-patch recordings and dynamic clamp that both the linearity and temporal fidelity of synaptic integration is improved by reducing Kv1 potassium channel conductance during inhibition, which counters membrane shunting even at high frequencies at which IPSPs sum. The reduction of peak excitation by preceding inhibition lowers spike probability, narrowing but not shifting the window for detecting binaural coincidence. The interplay between inhibition and potassium conductances thus improves the consistency and resolution of ITD coding across different frequencies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.