ArticleNeuron2013
Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
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- An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo.eLife · 2023Article
- Regulation of axon pathfinding by astroglia across genetic model organisms.Frontiers in cellular neuroscience · 2023Review
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- Visualization of binding patterns for five Leucine-rich repeat proteins in themicroPublication biology · 2019Article
- Identification of four Drosophila Toll-related proteins as ligands for the PTP69D receptor tyrosine phosphatase.microPublication biology · 2019Article
- Next-Generation Sequencing Reveals Increased Anti-oxidant Response and Ecdysone Signaling in STAT Supercompetitors inG3 (Bethesda, Md.) · 2019Article
- Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila.Development, growth & differentiation · 2019Review
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- Mechanisms of cell competition emerging from Drosophila studies.Current opinion in cell biology · 2017Article
- Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible.BMC genomics · 2017Article
- Article
- Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Genome biology · 2017Article
- Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster.BMC genomics · 2017Article
- Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.Seminars in cell & developmental biology · 2015Review
- R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development.Seminars in cell & developmental biology · 2015Review
- Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation.Development (Cambridge, England) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We developed a screening method for orphan receptor ligands, in which cell-surface proteins are expressed in Drosophila embryos from GAL4-dependent insertion lines and ligand candidates identified by the presence of ectopic staining with receptor fusion proteins. Stranded at second (Sas) binds to the receptor tyrosine phosphatase Ptp10D in embryos and in vitro. Sas and Ptp10D can interact in trans when expressed in cultured cells. Interactions between Sas and Ptp10D on longitudinal axons are required to prevent them from abnormally crossing the midline. Sas is expressed on both neurons and glia, whereas Ptp10D is restricted to CNS axons. We conducted epistasis experiments by overexpressing Sas in glia and examining how the resulting phenotypes are changed by removal of Ptp10D from neurons. We find that neuronal Ptp10D restrains signaling by overexpressed glial Sas, which would otherwise produce strong glial and axonal phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.