Evidence map›Paper›PMID 23764256›Full record

ReviewDevelopmental and comparative immunology2014

Insights from natural host-parasite interactions: the Drosophila model.

Erin S Keebaugh, Todd A Schlenke

Abstract readReview
In one paragraph

Review in Developmental and comparative immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. ThebioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Neuroscience insights · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. The non-oral infection of larvalFrontiers in immunology · 2022
    Article
  12. Article
  13. Article
  14. International journal of molecular sciences · 2021
    Review
  15. Host-Parasite Interaction of Atlantic salmon (Frontiers in immunology · 2021
    Article
  16. Review
  17. Article
  18. The Role of Lozenge inMolecules and cells · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erin S KeebaughDepartment of Biology, Emory University, 1510 Clifton Road, Atlanta, GA, United States. Electronic address: ekeebau@emory.edu.
Todd A Schlenke

Funding

A Model System For Host-Pathogen Interactions: Drosophila And Its Parasitic WaspsR01AI081879 · NIAID · UNIVERSITY OF ARIZONA · PI SCHLENKE, TODD ALEXANDER · 2009 to 2017
$2.8M
NIAID NIH HHS R01 AI081879
6 · The paper itself

Abstract

Immune responses against opportunistic pathogens have been extensively studied in Drosophila, leading to a detailed map of the genetics behind innate immunity networks including the Toll, Imd, Jak-Stat, and JNK pathways. However, immune mechanisms of other organisms, such as plants, have primarily been investigated using natural pathogens. It was the use of natural pathogens in plant research that revealed the plant R-Avr system, a specialized immune response derived from antagonistic coevolution between plant immune proteins and their natural pathogens' virulence proteins. Thus, we recommend that researchers begin to use natural Drosophila pathogens to identify novel immune strategies that may have arisen through antagonistic coevolution with common natural pathogens. In this review, we address the benefits of using natural pathogens in research, describe the known natural pathogens of Drosophila, and discuss the future prospects for research on natural pathogens of Drosophila.

Indexed as

Host-Parasite InteractionsAnimalsBiological EvolutionDrosophila melanogasterHumansImmunity, InnateModels, AnimalNuclear ProteinsOpportunistic InfectionsPlant ProteinsPlantsSymbiosisVirulence FactorsNuclear ProteinsPlant ProteinsR protein, Zea maysVirulence FactorsCoevolutionDrosophila immunityNatural pathogens

Identifiers

PMID23764256
PMCPMC3808516

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.