ArticleCell calcium2013
TRPC1-mediated Ca2+ and Na+ signalling in astroglia: differential filtering of extracellular cations.
Article in Cell calcium, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- IP3R2-Mediated Astrocytic CaCells · 2025Article
- Toll-like receptor 4 activation enhances Orai1-mediated calcium signal promoting cytokine production in spinal astrocytes.Cell calcium · 2022Article
- Influence of atherosclerosis on the molecular expression of the TRPC1/BK signal complex in the aortic smooth muscles of mice.Experimental and therapeutic medicine · 2022Article
- Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes.Neurochemical research · 2021Article
- Astrocytes: The Housekeepers and Guardians of the CNS.Advances in neurobiology · 2021Article
- Calcium Signals in Astrocyte Microdomains, a Decade of Great Advances.Frontiers in cellular neuroscience · 2021Review
- Physiology of Astroglial Excitability.Function (Oxford, England) · 2020Article
- Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Physiology of Astroglia.Advances in experimental medicine and biology · 2019Review
- Astroglia in Alzheimer's Disease.Advances in experimental medicine and biology · 2019Review
- Potassium and sodium microdomains in thin astroglial processes: A computational model study.PLoS computational biology · 2018Article
- Crosslink between calcium and sodium signalling.Experimental physiology · 2018Review
- Physiology of Astroglia.Physiological reviews · 2018Review
- TRPC1 Channels Are Expressed in Pyramidal Neurons and in a Subset of Somatostatin Interneurons in the Rat Neocortex.Frontiers in neuroanatomy · 2018Article
- TRPC1- and TRPC3-dependent CaGlia · 2017Article
- Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter.Neurochemical research · 2017Article
- Mitochondria control store-operated CaThe EMBO journal · 2017Article
- Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior.Frontiers in cellular neuroscience · 2017Review
- Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone.Neuroscience · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
Abstract
Canonical transient receptor potential 1 (TRPC1) plasmalemmal cation channels mediate Ca2+ and Na+ fluxes and control respective cytoplasmic ion signals in rat cortical astrocytes. Mechanical stimulation of astrocytes results in an increase in the levels of cytosolic Ca2+ and Na+ that are in part due to entry of extracellular cations through TRPC1 containing channels. Inhibition of the TRPC1 pore with an antibody against its selective filter reduced cytosolic Ca2+ accumulation caused by mechanical stimulation. In contrast, this immunological treatment increased the cytosolic Na+ peak accumulation induced by mechanical stimulation. We propose that TRPC channels are amenable to changes in selective filtering, as mutations in previous studies and antibody binding in our present study differentially affect the flux of Ca2) and Na+. TRPC1 containing channels might represent focal points for co-ordination of Ca2+ and Na+ signalling in astroglia and this can have consequences on Ca(2+)- and Na(+)-dependent processes such as regulated exocytosis and lactate production, respectively, which in turn can modulate neuronal synaptic transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.