ArticleThe Journal of allergy and clinical immunology2013
Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 87 citations in OpenAlex.
- The alpha-gal syndrome: Understanding the role of tick bites, and the delays in severe anaphylaxis.Allergy and asthma proceedings · 2026Review
- The role of immunoglobulin E in non-atopic disorders.Frontiers in immunology · 2025Review
- Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond.Current allergy and asthma reports · 2024Review
- The future of food allergy diagnosis.Frontiers in allergy · 2024Review
- Food Allergies and Parasites in Children.Foods (Basel, Switzerland) · 2023Review
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- Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host.PLoS neglected tropical diseases · 2021Article
- Patterns of allergic sensitization and factors associated with emergence of sensitization in the rural tropics early in the life course: findings of an Ecuadorian birth cohort.Frontiers in allergy · 2021Article
- Lack of Consistent Association between Asthma, Allergic Diseases, and Intestinal Helminth Infection in School-Aged Children in the Province of Bengo, Angola.International journal of environmental research and public health · 2021Article
- The microbial origins of food allergy.The Journal of allergy and clinical immunology · 2021Review
- Article
- Risk factors associated with rhinitis, allergic conjunctivitis and eczema among schoolchildren in Uganda.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6.The Journal of allergy and clinical immunology · 2020Article
- Regulation of IgE by T follicular helper cells.Journal of leukocyte biology · 2020Review
- A WAO - ARIA - GAThe World Allergy Organization journal · 2020Article
- Worms: Pernicious parasites or allies against allergies?Parasite immunology · 2019Review
- Parasites and allergy: Observations from Africa.Parasite immunology · 2019Review
- Recombinant glycoproteins resembling carbohydrate-specific IgE epitopes from plants, venoms and mites.EBioMedicine · 2019Article
- Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration.ERJ open research · 2018Article
- Identification of dominant anti-glycan IgE responses in school children by glycan microarray.The Journal of allergy and clinical immunology · 2018Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundThe prevalence of peanut allergy has increased in developed countries, but little is known about developing countries with high peanut consumption and widespread parasitic infections.
objectiveWe sought to investigate peanut allergy in Ghana.
methodsIn a cross-sectional survey among Ghanaian schoolchildren (n = 1604), data were collected on reported adverse reactions to peanut, peanut sensitization (serum specific IgE and skin reactivity), consumption patterns, and parasitic infections. In a subset (n = 43) IgE against Ara h 1, 2, 3, and 9 as well as cross-reactive carbohydrate determinants (CCDs) was measured by using ImmunoCAP. Cross-reactivity and biological activity were investigated by means of ImmunoCAP inhibition and basophil histamine release, respectively.
resultsAdverse reactions to peanut were reported in 1.5%, skin prick test reactivity in 2.0%, and IgE sensitization (≥0.35 kU/L) in 17.5% of participants. Moreover, 92.4% of those IgE sensitized to peanut (≥0.35 kU/L) had negative peanut skin prick test responses. Schistosoma haematobium infection was positively associated with IgE sensitization (adjusted odds ratio, 2.29; 95% CI, 1.37-3.86). In the subset IgE titers to Ara h 1, 2, 3, and 9 were low (<1.3 kU/L), except for 6 moderately strong reactions to Ara h 9. IgE against peanut was strongly correlated with IgE against CCDs (r = 0.89, P < .0001) and could be almost completely inhibited by CCDs, as well as S haematobium soluble egg antigen. Moreover, IgE to peanut showed poor biological activity.
conclusionsParasite-induced IgE against CCDs might account largely for high IgE levels to peanut in our study population of Ghanaian schoolchildren. No evidence of IgE-mediated peanut allergy was found.
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