Evidence map›Paper›PMID 23763766›Full record

ArticleVirology2013

Novel pneumoviruses (PnVs): Evolution and inflammatory pathology.

Stephanie F Glineur, Randall W Renshaw, Caroline M Percopo, Kimberly D Dyer, Edward J Dubovi, Joseph B Domachowske, Helene F Rosenberg

Abstract read
In one paragraph

Article in Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie F GlineurInflammation Immunobiology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1883, USA.
Randall W Renshaw
Caroline M Percopo
Kimberly D Dyer
Edward J Dubovi
Joseph B Domachowske
Helene F Rosenberg

Funding

Inflammation and Therapy for Respiratory Virus InfectionZIAAI000943 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENBERG, HELENE · 2009 to 2020
$7.4M
Inflammation and Therapy for Respiratory Virus InfectionZ01AI000943 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI ROSENBERG, HELENE · 2004 to 2008
$1.6M
Intramural NIH HHS Z01 AI000943Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIA AI000943NIAID NIH HHS AI000943NIAID NIH HHS Y99 AI999999
6 · The paper itself

Abstract

A previous report of a novel pneumovirus (PnV) isolated from the respiratory tract of a dog described its significant homology to the rodent pathogen, pneumonia virus of mice (PVM). The original PnV-Ane4 pathogen replicated in and could be re-isolated in infectious state from mouse lung but elicited minimal mortality compared to PVM strain J3666. Here we assess phylogeny and physiologic responses to 10 new PnV isolates. The G/glycoprotein sequences of all PnVs include elongated amino-termini when compared to the characterized PVMs, and suggest division into groups A and B. While we observed significant differences in cytokine production and neutrophil recruitment to the lungs of BALB/c mice in response to survival doses (50 TCID50 units) of representative group A (114378-10-29-KY-F) and group B (7968-11-OK) PnVs, we observed no evidence for positive selection (dN > dS) among the PnV/PnV, PVM/PnV or PVM/PVM G/glycoprotein or F/fusion protein sequence pairs.

Indexed as

Evolution, MolecularAmino Acid SequenceAnimalsGlycoproteinsInflammationLungMembrane GlycoproteinsMiceMice, Inbred BALB CMolecular Sequence DataMurine pneumonia virusPhylogenyPneumovirusPneumovirus InfectionsViral ProteinsGlycoproteinsMembrane GlycoproteinsViral ProteinsChemokineInflammationNeutrophilType I interferon

Identifiers

PMID23763766
PMCPMC3722285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.