ArticleAmerican journal of respiratory cell and molecular biology2013
Longitudinal, noninvasive monitoring of compensatory lung growth in mice after pneumonectomy via (3)He and (1)H magnetic resonance imaging.
Article in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 31 citations in OpenAlex.
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- The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in preclinical pulmonary structure-function studies.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- A pneumonectomy model to study flow-induced pulmonary hypertension and compensatory lung growth.Cell reports methods · 2023Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Validating in vivo hyperpolarizedMagnetic resonance in medicine · 2021Article
- Application of a stretched-exponential model for morphometric analysis of accelerated diffusion-weighted 129Xe MRI of the rat lung.Magma (New York, N.Y.) · 2021Article
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- Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion.PloS one · 2020Article
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- Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?The Journal of pediatrics · 2017Review
- Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Imaging mouse lung allograft rejection with (1)H MRI.Magnetic resonance in medicine · 2015Article
- Localization and stretch-dependence of lung elastase activity in development and compensatory growth.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Mouse pneumonectomy model of compensatory lung growth.Journal of visualized experiments : JoVE · 2014Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In rodents and some other mammals, partial pneumonectomy (PNX) of adult lungs results in rapid compensatory lung growth. In the past, quantification of compensatory lung growth and realveolarization could only be accomplished after killing the animal, removal of lungs, and histologic analysis of lungs at single time points. Hyperpolarized (3)He diffusion magnetic resonance imaging (MRI) allows in vivo morphometry of human lungs; our group has adapted this technique for application to mouse lungs. Through imaging, we can obtain maps of lung microstructural parameters that allow quantification of morphometric and physiologic measurements. In this study, we employed our (3)He MRI technique to image in vivo morphometry at baseline and to serially assess compensatory growth after left PNX of mice. (1)H and hyperpolarized (3)He diffusion MRI were performed at baseline (pre-PNX), 3-days, and 30-days after PNX. Compared with the individual mouse's own baseline, MRI was able to detect and serially quantify changes in lung volume, alveolar surface area, alveolar number, and regional changes in alveolar size that occurred during the course of post-PNX lung growth. These results are consistent with morphometry measurements reported in the literature for mouse post-PNX compensatory lung growth. In addition, we were also able to serially assess and quantify changes in the physiologic parameter of lung compliance during the course of compensatory lung growth; this was consistent with flexiVent data. With these techniques, we now have a noninvasive, in vivo method to serially assess the effectiveness of therapeutic interventions on post-PNX lung growth in the same mouse.
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