ArticleTransfusion2013
Restless legs syndrome, pica, and iron status in blood donors.
Article in Transfusion, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250298 (Pilot Study to Gain First Indications for the Impact of a Three-month's Oral Intake of an Iron Supplement With High Bioavailability on the Hemoglobin Concentration in Iron Deficient Blood Donors), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study to Gain First Indications for the Impact of a Three-month's Oral Intake of an Iron Supplement With High Bioavailability on the Hemoglobin Concentration in Iron Deficient Blood Donors
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Large genome-wide association study identifies three novel risk variants for restless legs syndrome.Communications biology · 2020Pooled it
- Restless legs syndrome associated with major diseases: A systematic review and new concept.Neurology · 2016Pooled it
- The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trial.Scientific reports · 2020Trial
- The benefits of iron supplementation following blood donation vary with baseline iron status.American journal of hematology · 2020Trial
- Trial
- Qualitative assessment of pica experienced by frequent blood donors.Transfusion · 2017Trial
- A randomized, blinded, placebo-controlled trial of education and iron supplementation for mitigation of iron deficiency in regular blood donors.Transfusion · 2016Trial
- Trial
- The strategies to reduce iron deficiency in blood donors randomized trial: design, enrolment and early retention.Vox sanguinis · 2015Trial
- Genome-wide association of pica within a cohort of volunteer blood donors potentially implicates the gene encoding neuropeptide VF.Transfusion · 2026Article
- Demographic, clinical, and biochemical predictors of pica in high-intensity blood donors.Transfusion medicine (Oxford, England) · 2022Article
- Ferritin Trajectories over Repeated Whole Blood Donations: Results from the FIND+ Study.Journal of clinical medicine · 2022Article
- A Comprehensive Examination of Severely Ill ME/CFS Patients.Healthcare (Basel, Switzerland) · 2021Article
- Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors.Transfusion · 2021Article
- Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome.Sleep · 2021Observational
- Association of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative study.Transfusion · 2019Article
- The effect of donation activity dwarfs the effect of lifestyle, diet and targeted iron supplementation on blood donor iron stores.PloS one · 2019Article
- Article
- Blood donation and anemia.Canadian family physician Medecin de famille canadien · 2016Article
- Ask about ice, then consider iron.Journal of the American Association of Nurse Practitioners · 2016Article
Corrections and comments
- Commented on byIron and ice.2013
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe association of blood donation-related iron deficiency with pica or restless legs syndrome (RLS) remains poorly elucidated. This study evaluated the prevalence of RLS and pica in blood donors completing the REDS-II Iron Status Evaluation (RISE) study. STUDY DESIGN AND
methodsRISE enrolled 2425 blood donors in a prospective cohort study; 1334 donors provided blood samples to characterize iron status and answered a questionnaire inquiring into symptoms of RLS and pica at a final visit after 15 to 24 months of follow-up. Associations between both conditions and iron status were evaluated.
resultsThere were 9 and 20% of donors reporting symptoms of probable or probable/possible RLS, respectively. Iron depletion and donation intensity were not predictive of RLS. Pica was reported by 65 donors (5.5%), half of whom reported daily cravings. Prevalence of pica increased with degree of iron depletion in women (2% in iron-replete females, 13% in those with ferritin < 12 ng/mL), but not in men. Probable RLS and pica coexpressed in eight individuals, but no more frequently than expected by chance.
conclusionRLS and pica have been associated with iron deficiency in nondonor populations. This study indicates a potentially high prevalence of RLS in frequent blood donors but shows no association with iron status or donation intensity. Low iron stores were associated with higher prevalence of pica, but only in females. Furthermore, the results are incompatible with RLS and pica sharing a common pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.