ReviewJournal of neuroendocrinology2013
Stroke neuroprotection: oestrogen and insulin-like growth factor-1 interactions and the role of microglia.
Review in Journal of neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Growth Hormone and Brain Regeneration: Evidence from Clinical Studies in Dementia, Traumatic Brain Injury, and Stroke: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field.Frontiers in aging neuroscience · 2023Review
- BDNF-overexpressing MSCs delivered by hydrogel in acute ischemic stroke treatment.Annals of translational medicine · 2022Article
- Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations.Frontiers in cellular neuroscience · 2022Review
- Glial estradiol synthesis after brain injury.Current opinion in endocrine and metabolic research · 2021Article
- Sex differences in recovery of motor function in a rhesus monkey model of cortical injury.Biology of sex differences · 2021Article
- Estrogen as a Neuroprotectant in Both Sexes: Stories From the Bird Brain.Frontiers in neurology · 2020Review
- Crosstalk between Inflammation and the BBB in Stroke.Current neuropharmacology · 2020Article
- Sexually dimorphic microglia and ischemic stroke.CNS neuroscience & therapeutics · 2019Review
- Mycoplasma contamination affects cell characteristics and decreases the sensitivity of BV2 microglia to LPS stimulation.Cytotechnology · 2019Article
- Ojayeonjonghwan, an oriental medicine composed of five seeds, protects against vasomotor and neurological disorders in estrogen-deficient rats.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Stroke and the neurovascular unit: glial cells, sex differences, and hypertension.American journal of physiology. Cell physiology · 2019Article
- Altered levels of circulating insulin-like growth factor I (IGF-I) following ischemic stroke are associated with outcome - a prospective observational study.BMC neurology · 2018Observational
- Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females.Physiology & behavior · 2018Review
- Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury.Progress in neurobiology · 2017Review
- The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats.Journal of neuroinflammation · 2016Article
- Estrogens, Neuroinflammation, and Neurodegeneration.Endocrine reviews · 2016Review
- G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells.Journal of neurochemistry · 2015Article
- Epigenetic regulation of estrogen-dependent memory.Frontiers in neuroendocrinology · 2014Review
- The impact of microglial activation on blood-brain barrier in brain diseases.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oestrogen has been shown to be neuroprotective for stroke and other neural injury models. Oestrogen promotes a neuroprotective phenotype through myriad actions, including stimulating neurogenesis, promoting neuronal differentiation and survival, suppressing neuroinflammation and maintaining the integrity of the blood-brain barrier. At the molecular level, oestrogen directly modulates genes that are beneficial for repair and regeneration via the canonical oestrogen receptor. Increasingly, evidence indicates that oestrogen acts in concert with growth factors to initiate neuroprotection. Oestrogen and insulin-like growth factor (IGF)-1 act cooperatively to influence cell survival, and combined steroid hormone/growth factor interaction has been well documented in the context of neurones and astrocytes. Here, we summarise the evidence that oestrogen-mediated neuroprotection is critically dependent on IGF-1 signalling, and specifically focus on microglia as the source of IGF-1 and the locus of oestrogen-IGF-1 interactions in stroke neuroprotection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.