ArticleBioMed research international2013
Hypoglycemic and hypolipidemic potential of a high fiber diet in healthy versus diabetic rabbits.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Synergistic antidiabetic efficacy of dorzolamide and metformin: HPTLC quantification and biological evaluation.Scientific reports · 2026Article
- Sustainable Farming: Nanofiber from the Pupunha Heart of Palm Sheath (Veterinary sciences · 2025Article
- Evaluation of the Accuracy of FreeStyle Libre 2 for Glucose Monitoring in White New Zealand Rabbits.Veterinary medicine and science · 2025Article
- Arabic gum ameliorates systemic modulation in Alloxan monohydrate-induced diabetic rats.Scientific reports · 2023Article
- Inclusion of Soybean Hulls (Animals : an open access journal from MDPI · 2023Article
- Practical considerations for reducing mortality rates in alloxan-induced diabetic rabbits.Heliyon · 2020Article
- Renoprotective Effect ofJournal of pharmacopuncture · 2019Article
- Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits.BMC complementary and alternative medicine · 2017Article
- Hypoglycemic Effect due to Insulin Stimulation with Plantago major in Wistar Rats.Medicinal & aromatic plants · 2017Article
- Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits.Journal of diabetes research · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in the diet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of 18 rabbits were used. The first group was fed with standard chow and the second with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). On day 14 diabetes mellitus was induced by the intravenous administration of alloxan (80 mg/kg). After an oral glucose load (3 g), glucose, insulin, and other biochemical parameters were determined on day 14 (healthy rabbits) and on day 28 (diabetic rabbits). In healthy rabbits, fiber did not modify glucose or insulin levels but decreased significantly total cholesterol, LDL-cholesterol, atherogenic index, and glycosylated hemoglobin. In diabetic rabbits, fiber was more beneficial in mild diabetics than in severe diabetics with significant decreases in glucose levels and increases in insulin concentrations. In these animals fiber caused an important reduction in cholesterol, indicating a beneficial effect of Plantago ovata husk in diabetic rabbits. Although further studies in patients are necessary, we think that Plantago ovata husk offers interesting perspectives to be administered to patients with diabetes mellitus.
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