ArticleBioMed research international2013
Analysis of complete genomes of Propionibacterium acnes reveals a novel plasmid and increased pseudogenes in an acne associated strain.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03450369 (A Phase 1B Dose Escalating Study of the Safety, Short-Term Engraftment and Action of a Singly-Applied NB01 in Adults With Moderate Acne), which is not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1B Dose Escalating Study of the Safety, Short-Term Engraftment and Action of a Singly-Applied NB01 in Adults With Moderate Acne
Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Unique genetic diversity of Propionibacterium acnes isolated from human facial skins in Thailand revealed by the multi-locus sequence typing scheme.BMC microbiology · 2025Article
- Comparative genomics analysis of six Cutibacterium acnes strains isolated from contaminated platelet concentrates.Access microbiology · 2025Article
- Genetic and Functional Analyses of Cutibacterium Acnes Isolates Reveal the Association of a Linear Plasmid with Skin Inflammation.The Journal of investigative dermatology · 2024Article
- Comparative Genomic Analysis ofMicroorganisms · 2023Article
- Genomic Characterization of 2Pathogens & immunity · 2023Article
- Evolving approaches to profiling the microbiome in skin disease.Frontiers in immunology · 2023Review
- Cobamide Sharing Is Predicted in the Human Skin Microbiome.mSystems · 2022Article
- Identification of a Transferable Linear Plasmid Carrying the Macrolide-Clindamycin Resistance GeneMicrobiology resource announcements · 2022Article
- Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting.PLoS pathogens · 2022Article
- Anatomy promotes neutral coexistence of strains in the human skin microbiome.Cell host & microbe · 2022Article
- Genomic Analysis ofMicroorganisms · 2021Article
- Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.Microorganisms · 2021Review
- MG-MLST: Characterizing the Microbiome at the Strain Level in Metagenomic Data.Microorganisms · 2020Article
- The grease trap: uncovering the mechanism of the hydrophobic lid inJournal of lipid research · 2020Article
- Article
- Applications of Human Skin Microbiota in the Cutaneous Disorders for Ecology-Based Therapy.Frontiers in cellular and infection microbiology · 2020Review
- The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions.Microorganisms · 2019Review
- Potential Role of the Microbiome in Acne: A Comprehensive Review.Journal of clinical medicine · 2019Review
- Acne, the Skin Microbiome, and Antibiotic Treatment.American journal of clinical dermatology · 2019Review
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The human skin harbors a diverse community of bacteria, including the Gram-positive, anaerobic bacterium Propionibacterium acnes. P. acnes has historically been linked to the pathogenesis of acne vulgaris, a common skin disease affecting over 80% of all adolescents in the US. To gain insight into potential P. acnes pathogenic mechanisms, we previously sequenced the complete genome of a P. acnes strain HL096PA1 that is highly associated with acne. In this study, we compared its genome to the first published complete genome KPA171202. HL096PA1 harbors a linear plasmid, pIMPLE-HL096PA1. This is the first described P. acnes plasmid. We also observed a five-fold increase of pseudogenes in HL096PA1, several of which encode proteins in carbohydrate transport and metabolism. In addition, our analysis revealed a few island-like genomic regions that are unique to HL096PA1 and a large genomic inversion spanning the ribosomal operons. Together, these findings offer a basis for understanding P. acnes virulent properties, host adaptation mechanisms, and its potential role in acne pathogenesis at the strain level. Furthermore, the plasmid identified in HL096PA1 may potentially provide a new opportunity for P. acnes genetic manipulation and targeted therapy against specific disease-associated strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.