ReviewBioMed research international2013
The potential roles of 18F-FDG-PET in management of acute stroke patients.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- In Vivo Quantification of Myelin Injury Following Ischemic Stroke.Molecular imaging and biology · 2026Article
- Intense FDG Activity of the Brain Caused by Cerebral Hypoperfusion.Clinical nuclear medicine · 2026Article
- Understanding ischemia in children with tuberculous meningitis (iThemba): a protocol paper.BMC pediatrics · 2026Article
- Comparison of the Correlation Between Cerebral [Molecular imaging and biology · 2025Article
- Alteration of brain metabolism in lacunar stroke based onFrontiers in neurology · 2025Article
- PET imaging of synaptic vesicle glycoprotein 2 subtype A for neurological recovery in ischemic stroke.European journal of nuclear medicine and molecular imaging · 2024Article
- Remote ischemic preconditioning plays a neuroprotective role in cerebral ischemia-reperfusion mice by inhibiting mitophagy.Heliyon · 2024Article
- Mechanism of Action and Translational Potential of (Stroke · 2024Article
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- The Vessel Has Been Recanalized: Now What?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice.International journal of biological sciences · 2023Article
- Stroke and molecular imaging: a focus on FDG-PET.American journal of nuclear medicine and molecular imaging · 2023Review
- Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-Fluorodeoxyglucose Positron Emission Tomography.Neuroscience bulletin · 2022Article
- Effect of Graded Targeted Temperature Management on Cerebral Glucose Spatiotemporal Characteristics after Cardiac Arrest.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- Emerging role of PARP-1 and PARthanatos in ischemic stroke.Journal of neurochemistry · 2022Review
- Cerebral glucose metabolism changes in chronic ischemia patients following subcranial-intracranial bypass.Neurosurgical review · 2020Article
- CD271Experimental and therapeutic medicine · 2020Article
- Initial experience with [European journal of nuclear medicine and molecular imaging · 2020Article
- Positron Emission Tomography After Ischemic Brain Injury: Current Challenges and Future Developments.Translational stroke research · 2020Review
- Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease.European journal of nuclear medicine and molecular imaging · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive efforts have recently been devoted to developing noninvasive imaging tools capable of delineating brain tissue viability (penumbra) during acute ischemic stroke. These efforts could have profound clinical implications for identifying patients who may benefit from tPA beyond the currently approved therapeutic time window and/or patients undergoing neuroendovascular treatments. To date, the DWI/PWI MRI and perfusion CT have received the most attention for identifying ischemic penumbra. However, their routine use in clinical settings remains limited. Preclinical and clinical PET studies with [(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) have consistently revealed a decreased (18)F-FDG uptake in regions of presumed ischemic core. More importantly, an elevated (18)F-FDG uptake in the peri-ischemic regions has been reported, potentially reflecting viable tissues. To this end, this paper provides a comprehensive review of the literature on the utilization of (14)C-2-DG and (18)F-FDG-PET in experimental as well as human stroke studies. Possible cellular mechanisms and physiological underpinnings attributed to the reported temporal and spatial uptake patterns of (18)F-FDG are addressed. Given the wide availability of (18)F-FDG in routine clinical settings, (18)F-FDG PET may serve as an alternative, non-invasive tool to MRI and CT for the management of acute stroke patients.
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