ArticleInternational journal of breast cancer2013
The mammary gland carcinogens: the role of metal compounds and organic solvents.
Article in International journal of breast cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Occupational Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-Analysis.La Medicina del lavoro · 2024Pooled it
- Occupational exposure to organic solvents and breast cancer risk: a systematic review and meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Composition and Functional Potential of the Human Mammary Microbiota Prior to and Following Breast Tumor Diagnosis.mSystems · 2022Article
- Metals and Breast Cancer Risk: A Prospective Study Using Toenail Biomarkers.American journal of epidemiology · 2021Article
- Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review.Cancers · 2019Review
- Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study.Clinical and experimental medicine · 2016Article
- Xenobiotic transporter expression along the male genital tract.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increased rate of breast cancer incidences especially among postmenopausal women has been reported in recent decades. Despite the fact that women who inherited mutations in the BRCA1 and BRCA2 genes have a high risk of developing breast cancer, studies have also shown that significant exposure to certain metal compounds and organic solvents also increases the risks of mammary gland carcinogenesis. While physiological properties govern the uptake, intracellular distribution, and binding of metal compounds, their interaction with proteins seems to be the most relevant process for metal carcinogenicity than biding to DNA. The four most predominant mechanisms for metal carcinogenicity include (1) interference with cellular redox regulation and induction of oxidative stress, (2) inhibition of major DNA repair, (3) deregulation of cell proliferation, and (4) epigenetic inactivation of genes by DNA hypermethylation. On the other hand, most organic solvents are highly lipophilic and are biotransformed mainly in the liver and the kidney through a series of oxidative and reductive reactions, some of which result in bioactivation. The breast physiology, notably the parenchyma, is embedded in a fat depot capable of storing lipophilic xenobiotics. This paper reviews the role of metal compounds and organic solvents in breast cancer development.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.