ArticleJournal of nutrition and metabolism2013
Fructose: a key factor in the development of metabolic syndrome and hypertension.
Article in Journal of nutrition and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Fructose-containing food sources and blood pressure: A systematic review and meta-analysis of controlled feeding trials.PloS one · 2023Pooled it
- Important Food Sources of Fructose-Containing Sugars and Incident Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Journal of the American Heart Association · 2019Pooled it
- Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population.International journal of medical sciences · 2016Pooled it
- NAFLD-related SNPs are linked to changes in liver fat, as measured by the CAP score, and serum lipids in response to a 3-week sugar-sweetened beverage intervention: a pilot study.Food & function · 2026Trial
- Dietary Fructose Alters Duodenal Mucin Glycosylation and Mucus Production in High-Fat Diet-Fed Mice.International journal of molecular sciences · 2026Article
- Honey as a Natural Flavorful Product: A Comprehensive Review of Its Potential Biological Activities and Recent Studies.Food science & nutrition · 2026Review
- Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting.BMC oral health · 2025Observational
- Effect of High Fructose Corn Syrup and Citric Acid in Broiler Diets on Performance, Gut pH, Immunity, Antioxidant Status and Some Blood Parameters.Veterinary medicine and science · 2025Article
- Fructose-Induced Impairment of Liver and Skeletal Muscle Metabolism Is Prevented by Administration of Shouchella clausii Spores by Preserving Mitochondrial Function and Insulin Sensitivity.Molecular nutrition & food research · 2025Article
- Establishing a Female Animal Model of Prediabetes Using a High-Carbohydrate, High-Fat Diet.Current issues in molecular biology · 2024Article
- Fructose Consumption Affects Placental Production of HNutrients · 2024Article
- Article
- Early aging and premature vascular aging in chronic kidney disease.Clinical kidney journal · 2023Review
- Snack consumption patterns and their associations with risk of incident metabolic syndrome: Tehran lipid and glucose study.Nutrition & metabolism · 2023Article
- Article
- The Sugar Metabolic Model ofJournal of fungi (Basel, Switzerland) · 2022Article
- Maternal Fructose Intake, Programmed Mitochondrial Function and Predisposition to Adult Disease.International journal of molecular sciences · 2022Review
- High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K/AKT/mitochondria signaling.Biomedical journal · 2022Article
- Guava Leaf Extract Suppresses Fructose Mediated Non-Alcoholic Fatty Liver Disease in Growing Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Folate Deficiency Increased Lipid Accumulation and Leptin Production of Adipocytes.Frontiers in nutrition · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus and the metabolic syndrome are becoming leading causes of death in the world. Identifying the etiology of diabetes is key to prevention. Despite the similarity in their structures, fructose and glucose are metabolized in different ways. Uric acid, a byproduct of uncontrolled fructose metabolism is known risk factor for hypertension. In the liver, fructose bypasses the two highly regulated steps in glycolysis, glucokinase and phosphofructokinase, both of which are inhibited by increasing concentrations of their byproducts. Fructose is metabolized by fructokinase (KHK). KHK has no negative feedback system, and ATP is used for phosphorylation. This results in intracellular phosphate depletion and the rapid generation of uric acid due to activation of AMP deaminase. Uric acid, a byproduct of this reaction, has been linked to endothelial dysfunction, insulin resistance, and hypertension. We present possible mechanisms by which fructose causes insulin resistance and suggest actions based on this association that have therapeutic implications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.