ArticlePloS one2013
A mechanochemical model of cell reorientation on substrates under cyclic stretch.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Cyclic stretch-regulated wound healing.Biophysical journal · 2023Article
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- A mechanistic motor-clutch model that explains cell shape dynamics to cyclic stretch.Molecular biology of the cell · 2022Article
- Cellular mechanics of wound formation in single cell layer under cyclic stretching.Biophysical journal · 2022Article
- Dynamic and static biomechanical traits of cardiac fibrosis.Frontiers in bioengineering and biotechnology · 2022Review
- Force-mediated cellular anisotropy and plasticity dictate the elongation dynamics of embryos.Science advances · 2021Article
- Effect of Cyclic Stretch on Neuron Reorientation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2020Article
- Dynamic Migration Modes of Collective Cells.Biophysical journal · 2018Article
- A general model of focal adhesion orientation dynamics in response to static and cyclic stretch.Communications biology · 2018Article
- Mechanical and Systems Biology of Cancer.Computational and structural biotechnology journal · 2018Review
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
- Biomechanics of cell reorientation in a three-dimensional matrix under compression.Experimental cell research · 2017Article
- A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion.Royal Society open science · 2016Article
- A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a theoretical study on the cyclic stretch-induced reorientation of spindle-shaped cells. Specifically, by taking into account the evolution of sub-cellular structures like the contractile stress fibers and adhesive receptor-ligand clusters, we develop a mechanochemical model to describe the dynamics of cell realignment in response to cyclically stretched substrates. Our main hypothesis is that cells tend to orient in the direction where the formation of stress fibers is energetically most favorable. We show that, when subjected to cyclic stretch, the final alignment of cells reflects the competition between the elevated force within stress fibers that accelerates their disassembly and the disruption of cell-substrate adhesion as well, and an effectively increased substrate rigidity that promotes more stable focal adhesions. Our model predictions are consistent with various observations like the substrate rigidity dependent formation of stable adhesions and the stretching frequency, as well as stretching amplitude, dependence of cell realignment. This theory also provides a simple explanation on the regulation of protein Rho in the formation of stretch-induced stress fibers in cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.