Trial reportPloS one2013
Effects of gastric irrigation on bacterial counts before endoscopic submucosal dissection: a randomized case control prospective study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Optimal definition of coagulation syndrome after colorectal endoscopic submucosal dissection: a post hoc analysis of randomized controlled trial.International journal of colorectal disease · 2021Trial
- Novel effective and repeatedly available ring-thread counter traction for safer colorectal endoscopic submucosal dissection.Surgical endoscopy · 2017Trial
- Antibiotic prophylaxis against electrocoagulation syndrome after esophageal endoscopic submucosal dissection: a single center retrospective study.Surgical endoscopy · 2026Article
- Development and validation of a model for predicting electrocoagulation syndrome after endoscopic full-thickness resection of gastric tumors.Surgical endoscopy · 2025Article
- High Joule heat as a risk factor for post-endoscopic submucosal dissection electrocoagulation syndrome: A multicenter prospective study.World journal of gastrointestinal endoscopy · 2024Article
- Nomogram for predicting electrocoagulation syndrome after endoscopic submucosal dissection of esophageal tumors.Surgical endoscopy · 2024Article
- High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection.World journal of gastroenterology · 2021Article
- A Rare Case of Delayed Perigastric Abscess after Curative Resection of Early Gastric Cancer by Uncomplicated Endoscopic Submucosal Dissection: Successful Treatment with Endoscopic Ultrasound-guided Drainage.Internal medicine (Tokyo, Japan) · 2021Article
- Updated evidence on endoscopic resection of early gastric cancer from Japan.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017Review
- Pretreatment Gastric Lavage Reduces Postoperative Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasms.PloS one · 2016Article
- Review of Pure Endoscopic Full-Thickness Resection of the Upper Gastrointestinal Tract.Gut and liver · 2015Review
- Establishment of the hybrid endoscopic full-thickness resection of gastric gastrointestinal stromal tumors.Molecular and clinical oncology · 2015Article
- Reduction effect of bacterial counts by preoperative saline lavage of the stomach in performing laparoscopic and endoscopic cooperative surgery.World journal of gastroenterology · 2014Article
- Analysis of the bacterial flora in the nasal cavity and the sphenoid sinus mucosa in patients operated on with an endoscopic endonasal transsphenoidal approach.Neurologia medico-chirurgica · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe antiseptic effect of gastric irrigation before endoscopic submucosal dissection (ESD) has not yet been reported. The aim of the randomized prospective study is to evaluate the antiseptic effects of gastric irrigation of saline solution before ESD by evaluating bacterial count.
methodsThis prospective randomized controlled trial included 50 patients diagnosed with early gastric cancer who were randomly divided into 2 groups (25 patients in each group) by using the opaque envelope method: the clean group (irrigation with 2 L saline solution before ESD) and the regular group (no irrigation). The gastric juice was collected and cultured before ESD. The entire stomach was irrigated using a water jet attached to an endoscope. After ESD with resection and removal of the tumor specimen, a postoperative culture of the gastric juice was obtained using the same method as the preoperative culture.
resultsThe mean log bacterial count of the post-gastric irrigation gastric juice was 5.08±0.75 in the regular group and 1.86±0.86 in the clean group. The difference in the bacterial counts was significant between the groups (P = 0.0004). The difference in the white blood cells (WBC) count on POD 1 was significant (P = 0.044). WBC count on POD 2 did not significantly differ between the groups (P = 0.3). The difference in the body temperature (BT) on POD 1 was significant (P = 0.017), On POD 2 the BT was not significant between the groups (P = 0.5). On POD 1, 88% of the patients in the regular group and 16% of the patients in the clean group had mild to moderate spontaneous pain (P = 0.0026). On POD 2 the proportion with mild to moderate spontaneous pain was 36% and 24% in the regular group and the clean group, respectively (P = 0.1).
conclusionPre-ESD gastric irrigation with saline solution is effective and feasible for suppressing infection during the ESD procedure with favorable clinical outcomes. TRIAL REGISTRATION INFORMATION: The university hospital medical information network (UMIN) #000008691.
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