ArticlePloS one2013
How fast does a signal propagate through proteins?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Framework for Quantifying the Efficiency of Competing Signal Transmission Modes in Proteins.Journal of the American Chemical Society · 2026Article
- Biophysical and Structural Features of αβT-Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T-Cell Activation.Immunological reviews · 2025Review
- A tool for visualizing protein motions in time-resolved crystallography.Structural dynamics (Melville, N.Y.) · 2020Article
- Coherent phenomena in photosynthetic light harvesting: part one-theory and spectroscopy.Biophysical reviews · 2018Review
- Characterization of the viscoelastic behavior of a simplified collagen micro-fibril based on molecular dynamics simulations.Journal of the mechanical behavior of biomedical materials · 2016Article
- Allosteric regulation of focal adhesion kinase by PIP₂ and ATP.Biophysical journal · 2015Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the molecular basis of signal propagation in the cell, proteins are regulated by perturbations, such as mechanical forces or ligand binding. The question arises how fast such a signal propagates through the protein molecular scaffold. As a first step, we have investigated numerically the dynamics of force propagation through a single (Ala)[Formula: see text] protein following a sudden increase in the stretching forces applied to its end termini. The force propagates along the backbone into the center of the chain on the picosecond scale. Both conformational and tension dynamics are found in good agreement with a coarse-grained theory of force propagation through semiflexible polymers. The speed of force propagation of [Formula: see text]50Å ps(-1) derived from these simulations is likely to determine an upper speed limit of mechanical signal transfer in allosteric proteins or molecular machines.
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