ArticlePloS one2013
Novel biodegradable porous scaffold applied to skin regeneration.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Fabrication and Characterization of Fish Tropocollagen Sponge Enriched with Nanodiamonds for Potential Wound Dressing Applications.Materials (Basel, Switzerland) · 2026Article
- Gelatin-based porous scaffolds: design concepts, production, and applications in precision regenerative medicine.Materials today. Bio · 2026Review
- Recent Advances in 3D Bioprinting of Porous Scaffolds for Tissue Engineering: A Narrative and Critical Review.Journal of functional biomaterials · 2025Review
- Chitosan based extruded nanofibrous bioscaffold for local delivery of mesenchymal stem cells to improve diabetic wound healing.Stem cell research & therapy · 2024Article
- Biopolymeric Insulin Membranes for Antimicrobial, Antioxidant, and Wound Healing Applications.Pharmaceutics · 2024Article
- Antibacterial, Anti-Biofilm, and Anti-Inflammatory Properties of Gelatin-Chitosan-Moringa-Biopolymer-Based Wound Dressings towardsPharmaceuticals (Basel, Switzerland) · 2024Article
- Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue.International journal of nanomedicine · 2024Article
- Effect of lyophilized gelatin-norbornene cryogel size on calvarial bone regeneration.Materials today. Bio · 2023Article
- Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications.Polymers · 2023Article
- Article
- Engineering of a Microscale Niche for Pancreatic Tumor Cells Using Bioactive Film Coatings Combined with 3D-Architectured Scaffolds.ACS applied materials & interfaces · 2022Article
- Adipose-Derived Stem Cell-Incubated HA-Rich Sponge Matrix Implant Modulates Oxidative Stress to Enhance VEGF and TGF-Oxidative medicine and cellular longevity · 2022Article
- Analysis of the Physico-Chemical, Mechanical and Biological Properties of Crosslinked Type-I Collagen from Horse Tendon: Towards the Development of Ideal Scaffolding Material for Urethral Regeneration.Materials (Basel, Switzerland) · 2021Article
- Advancements in the Delivery of Growth Factors and Cytokines for the Treatment of Cutaneous Wound Indications.Advances in wound care · 2021Article
- Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation.Pharmaceutics · 2021Article
- Fabrication and characterization of scaffolds containing different amounts of allantoin for skin tissue engineering.Scientific reports · 2021Article
- Article
- An Overview on Collagen and Gelatin-Based Cryogels: Fabrication, Classification, Properties and Biomedical Applications.Polymers · 2021Review
- Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials.Gels (Basel, Switzerland) · 2021Review
- [The research advances of three dimensional porous cryogel for tissue engineering].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Review
Corrections and comments
- Erratum issuedWang, Zhao-Ren [corrected to Wang, Chau-Zen]
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin wound healing is an important lifesaving issue for massive lesions. A novel porous scaffold with collagen, hyaluronic acid and gelatin was developed for skin wound repair. The swelling ratio of this developed scaffold was assayed by water absorption capacity and showed a value of over 20 g water/g dried scaffold. The scaffold was then degraded in time- and dose-dependent manners by three enzymes: lysozyme, hyaluronidase and collagenase I. The average pore diameter of the scaffold was 132.5±8.4 µm measured from SEM images. With human skin cells growing for 7 days, the SEM images showed surface fractures on the scaffold due to enzymatic digestion, indicating the biodegradable properties of this scaffold. To simulate skin distribution, the human epidermal keratinocytes, melanocytes and dermal fibroblasts were seeded on the porous scaffold and the cross-section immunofluorescent staining demonstrated normal human skin layer distributions. The collagen amount was also quantified after skin cells seeding and presented an amount 50% higher than those seeded on culture wells. The in vivo histological results showed that the scaffold ameliorated wound healing, including decreasing neutrophil infiltrates and thickening newly generated skin compared to the group without treatments.
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