ReviewDeutsches Arzteblatt international2013
Molecular genetic aspects of weight regulation.
Review in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Pooled it
- The monogenic forms of obesity in Saudi families.Human molecular genetics · 2026Article
- Unravelling obesity: from leptin to glucagon-like peptide-1 receptor agonists.Journal of applied genetics · 2026Review
- Toward standardized personalized nutrition: a methodological scoping review and meta-analysis of randomized controlled trials in adults with overweight and obesity.Genes & nutrition · 2026Article
- Effects of FTO Gene rs9939609 and rs17817449 Polymorphisms on Insulin Resistance in Turkish Children With Obesity.Journal of diabetes · 2026Observational
- Article
- Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity.Journal of personalized medicine · 2023Article
- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- Prevalence estimates of putatively pathogenic leptin variants in the gnomAD database.PloS one · 2022Article
- [Twin research in Germany].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021Review
- Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R).Physiological research · 2020Review
- Relevance of polymorphisms in MC4R and BDNF in short normal stature.BMC pediatrics · 2018Article
- A Novel Approach to the Nutrigenetics and Nutrigenomics of Obesity and Weight Management.Current oncology reports · 2016Review
- Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age.International journal of obesity (2005) · 2016Article
- Article
- Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies.Current obesity reports · 2015Review
- Cognitive and autonomic determinants of energy homeostasis in obesity.Nature reviews. Endocrinology · 2015Review
- Food reward system: current perspectives and future research needs.Nutrition reviews · 2015Review
- Gene-diet interaction and weight loss.Current opinion in lipidology · 2014Review
- Mitochondrial DNA variants in obesity.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamily and twin studies have empirically revealed a 40% to 70% heritability of body-mass index, yet only a few hereditary factors have been identified to date that increase the risk of being overweight.
methodsWe present the current state of molecular genetic research on obesity with a selective review of the literature.
resultsA number of monogenic recessive mutations causing obesity have been identified, but these are rare. Various dominant mutations of the melanocortin-4 receptor gene are found in about 1% to 4% of all markedly obese persons. Current molecular genetic research focuses on the identification of common DNA variants affecting body weight; the genetic material of hundreds of thousands of people from around the world has now been investigated in genome-wide association studies. More than 30 variants conferring an increased risk have been identified, most of which are single nucleotide polymorphisms (SNPs) of no immediately clear functional significance. On average, these variants raise body weight by 500 g (range, 180 to 1400 g). Aside from SNPs, variations in the number of copies of specific DNA sequences have also been linked to obesity, as well as to subnormal weight. All the hereditary factors that have been identified to date account for about 5% of the variability of BMI. Extrapolation yields figures ranging from 10% to 15%.
conclusionsThe amount of genetic variability seen to date at the DNA level accounts only for a small fraction of the inter-individual variability of BMI. Obesity is thought to be a largely hereditary condition; the fact that its genetic basis has not yet been demonstrated may be due to various genetic or experimental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.