Evidence map›Paper›PMID 23762127›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2013

Psychoneuroimmunology-Based Stress Management during Adjuvant Chemotherapy for Early Breast Cancer.

Jo Lynne W Robins, Nancy L McCain, R K Elswick, Jeanne M Walter, D Patricia Gray, Inez Tuck

Abstract read
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In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Guideline
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  8. Qigong in cancer care: a systematic review and construct analysis of effective Qigong therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Pooled it
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  10. Trial
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  12. Article
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  19. Tai chi chuan exercise for patients with breast cancer: a systematic review and meta-analysis.Evidence-based complementary and alternative medicine : eCAM · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jo Lynne W RobinsVirginia Commonwealth University School of Nursing, Richmond, VA 23298, USA.
Nancy L McCain
R K Elswick
Jeanne M Walter
D Patricia Gray
Inez Tuck

Funding

X-LINKED HYPOPHOSPHATEMIAM01RR000065 · NCRR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MAS, VALERIA RAQUEL · 1985 to 2010
$24.8M
PNI-BASED STRESS MANAGEMENT IN EARLY BREAST CANCERR01CA114718 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCCAIN, NANCY L · 2004 to 2008
$2.9M
NCI NIH HHS R01 CA114718NCRR NIH HHS M01 RR000065
6 · The paper itself

Abstract

Objective. In a randomized trial of women with early stage breast cancer undergoing adjuvant chemotherapy, two stress management interventions, tai chi training and spiritual growth groups, were compared to a usual care control group, to evaluate psychosocial functioning, quality of life (QOL), and biological markers thought to reflect cancer- and treatment-specific mechanisms. Method. The sample consisted of 145 women aged 27-75 years; 75% were Caucasian and 25% African American. A total of 109 participants completed the study, yielding a 75% retention rate. Grounded in a psychoneuroimmunology framework, the overarching hypothesis was that both interventions would reduce perceived stress, enhance QOL and psychosocial functioning, normalize levels of stress-related neuroendocrine mediators, and attenuate immunosuppression. Results. While interesting patterns were seen across the sample and over time, the interventions had no appreciable effects when delivered during the period of chemotherapy. Conclusions. Findings highlight the complex nature of biobehavioral interventions in relation to treatment trajectories and potential outcomes. Psychosocial interventions like these may lack sufficient power to overcome the psychosocial or physiological stress experienced during the chemotherapy treatment period. It may be that interventions requiring less activity and/or group attendance would have enhanced therapeutic effects, and more active interventions need to be tested prior to and following recovery from chemotherapy.

Identifiers

PMID23762127
PMCPMC3666296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.