Evidence map›Paper›PMID 23762094›Full record

ReviewClinical & developmental immunology2013

Neonatal sepsis due to coagulase-negative staphylococci.

Elizabeth A Marchant, Guilaine K Boyce, Manish Sadarangani, Pascal M Lavoie

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06893939 (Limited Versus Extended Trophic Feeding), which is not on this map. Cited by 83 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06893939 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Limited Versus Extended Trophic Feeding (LET-FEED) Trial

TypeinterventionalSponsorUniversity of WashingtonRan2025 to 2031Enrolled350ConditionsSepsis, Length of Stay, Mortality, Neurodevelopmental DelayArmsLimited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics)
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 212 citations in OpenAlex.

  1. Antibiotic regimens for late-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Journal of clinical medicine · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. TracingApplied and environmental microbiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Elizabeth A MarchantChild and Family Research Institute, 4th Floor, Translational Research Building, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.
Guilaine K Boyce
Manish Sadarangani
Pascal M Lavoie
University of British Columbia · CAChild and Family Research Institute · CA

Funding

CIHR 123478-1
6 · The paper itself

Abstract

Neonates, especially those born prematurely, are at high risk of morbidity and mortality from sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and immaturity of the innate immune system, put these infants at greater risk of developing infection. Although advanced neonatal care enables us to save even the most preterm neonates, the very interventions sustaining those who are hospitalized concurrently expose them to serious infections due to common nosocomial pathogens, particularly coagulase-negative staphylococci bacteria (CoNS). Moreover, the health burden from infection in these infants remains unacceptably high despite continuing efforts. In this paper, we review the epidemiology, immunological risk factors, diagnosis, prevention, treatment, and outcomes of neonatal infection due to the predominant neonatal pathogen CoNS.

Indexed as

Anti-Bacterial AgentsCoagulaseHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesIntensive Care Units, NeonatalSepsisStaphylococcal InfectionsStaphylococcusVirulenceAnti-Bacterial AgentsCoagulase

Identifiers

PMID23762094
PMCPMC3674645
OpenAlexW2041127220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.