ArticleInternational journal of endocrinology2013
Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis.
Article in International journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 152 citations in OpenAlex.
- Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial.Experimental biology and medicine (Maywood, N.J.) · 2021Trial
- Silicon in Poultry Nutrition: Biological Roles, Bioavailability, and Implications for Skeletal Health and Performance.Biological trace element research · 2026Review
- Dietary Silicon Supplementation Improves Egg Production Performance in Late-Phase Laying Hens: Roles of Antioxidant Capacity, Reproductive Hormones, and Serum Cu/Zn Regulation.Animals : an open access journal from MDPI · 2026Article
- Metalloids: Semi as Metals yet Full of Antimicrobial Potential.ChemMedChem · 2026Review
- Burn-Safe Biodegradable Magnetocaloric Composites for Temperature-Controlled Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparative Evaluation of the Bone Regenerative Potential of a Novel Calcium Silicate-Modified Calcium Carbonate Graft Material: Histological and Micro-Computed Tomography Assessment Using a Rat Calvarial Defect Model.Journal of functional biomaterials · 2025Article
- Exploring Silicone-Induced Lupus Through a Case Report.Mediterranean journal of rheumatology · 2025Article
- Role of TiScientific reports · 2024Article
- Interfaces between Cranial Bone and AISI 304 Steel after Long-Term Implantation: A Case Study of Cranial Screws.ACS biomaterials science & engineering · 2024Article
- Anti-osteoporosis activity of casticin in ovariectomized rats.Toxicology research · 2024Article
- Tuning biodegradability, bone-bonding capacity, and wear resistance of zinc-30% magnesium intermetallic alloy for use in load-bearing bone applications.Scientific reports · 2024Article
- MiR-210 improves postmenopausal osteoporosis in ovariectomized rats through activating VEGF/Notch signaling pathway.BMC musculoskeletal disorders · 2023Article
- Fast Degradable Calcium Phosphate Cement for Maxillofacial Bone Regeneration.Tissue engineering. Part A · 2023Article
- Heavy metal contamination in pristine environments: lessons from the Juan Fernandez fur seal (Royal Society open science · 2023Article
- Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients.Therapeutic advances in musculoskeletal disease · 2023Review
- Effect of moderate beer consumption (with and without ethanol) on osteoporosis in early postmenopausal women: Results of a pilot parallel clinical trial.Frontiers in nutrition · 2022Article
- Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid.Nutrients · 2021Review
- FK506 ameliorates osteoporosis caused by osteoblast apoptosis via suppressing the activated CaN/NFAT pathway during oxidative stress.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Silicon: A neglected micronutrient essential for bone health.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Utility of Chitra-HASi Granules in Cystic Defects of the Maxillofacial Region: A Pilot Study.Journal of pharmacy & bioallied sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physicians are aware of the benefits of calcium and vitamin D supplementation. However, additional nutritional components may also be important for bone health. There is a growing body of the scientific literature which recognizes that silicon plays an essential role in bone formation and maintenance. Silicon improves bone matrix quality and facilitates bone mineralization. Increased intake of bioavailable silicon has been associated with increased bone mineral density. Silicon supplementation in animals and humans has been shown to increase bone mineral density and improve bone strength. Dietary sources of bioavailable silicon include whole grains, cereals, beer, and some vegetables such as green beans. Silicon in the form of silica, or silicon dioxide (SiO2), is a common food additive but has limited intestinal absorption. More attention to this important mineral by the academic community may lead to improved nutrition, dietary supplements, and better understanding of the role of silicon in the management of postmenopausal osteoporosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.