Evidence map›Paper›PMID 23761989›Full record

ArticleClinical Medicine Insights. Oncology2013

Targeted therapies in the treatment of advanced hepatocellular carcinoma.

Zhengyu Wei, Cataldo Doria, Yuan Liu

Abstract read
In one paragraph

Article in Clinical Medicine Insights. Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation.Journal of clinical and translational hepatology · 2016
    Review
  5. Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy.Cellular and molecular gastroenterology and hepatology · 2015
    Article
  6. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study.Liver international : official journal of the International Association for the Study of the Liver · 2015
    Observational
  7. Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhengyu WeiDivision of Surgical Research, Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Camden, NJ.
Cataldo Doria
Yuan Liu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common liver cancer and the third leading cause of cancer death. It has been a major worldwide health problem with more new cases being diagnosed each year. The current available therapies for patients with advanced HCC are extremely limited. Therefore, it is of great clinical interests to develop more effective therapies for systemic treatment of advanced HCC. Several promising target-based drugs have been tested in a number of clinical trials. One breakthrough of these efforts is the approved clinical use of sorafenib in patients with advanced HCC. Targeted therapies are becoming an attractive option for the treatment of advanced HCC. In this review, we summarize the most recent progress in clinical targeted treatments of advanced HCC.

Indexed as

hepatocellular carcinoma (HCC)signaling pathwaysorafenibtargeted therapytumor inhibitor

Identifiers

PMID23761989
PMCPMC3667684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.