ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers.
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Who cites it
179 citing papers in PubMed, 319 citations in OpenAlex.
- Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D-Serine Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Cocaine facilitates CaMolecular psychiatry · 2026Article
- Ultrasonic repression of TRPA1-dependent astrocyte reactivity confers neuroprotection in models of Lewy body dementia.Translational neurodegeneration · 2026Article
- Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors.The Journal of physiology · 2026Article
- Subcortical neuroimaging signature of painful disorders of the trigeminal nerve: a UK Biobank study.The journal of headache and pain · 2026Article
- Physiological Roles of Hydrogen Sulfide/Polysulfides and Regulation of their Production.Handbook of experimental pharmacology · 2026Review
- Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function.Nature neuroscience · 2026Article
- Astrocyte Store-Released Calcium Modulates Visual Cortex Synapse Development and Circuit Function.Research square · 2025Article
- Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling.Cells · 2025Review
- Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- D-Serine's Journey Between Stars and Synapses.Neurochemical research · 2025Review
- Hydrogen sulfide/polysulfides signaling and neuronal diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- IP3R2-Mediated Astrocytic CaCells · 2025Article
- Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice.Glia · 2025Article
- Insights into the Involvement of TRPA1 Channels in the Neuro-Inflammatory Machinery of Trigeminal Neuralgia.Molecules (Basel, Switzerland) · 2025Article
- Astrocyte regulation of behavioral outputs: the versatile roles of calcium.Frontiers in cellular neuroscience · 2025Review
- Revisiting astrocytic calcium signaling in the brain.Fundamental research · 2024Review
- The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens.Molecular psychiatry · 2024Article
- Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes.Nature nanotechnology · 2024Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+) signals in hippocampal long-term potentiation (LTP), a form of synaptic plasticity involved in learning and memory, remains unclear. Here, we explored a recently discovered novel TRPA1 channel-mediated transmembrane Ca(2+) flux pathway in astrocytes. Specifically, we determined whether block or genetic deletion of TRPA1 channels affected LTP of Schaffer collateral to CA1 pyramidal neuron synapses. Using pharmacology, TRPA1(-/-) mice, imaging, electrophysiology, and D-serine biosensors, our data indicate that astrocyte TRPA1 channels contribute to basal Ca(2+) levels and are required for constitutive D-serine release into the extracellular space, which contributes to NMDA receptor-dependent LTP. The findings have broad relevance for the study of astrocyte-neuron interactions by demonstrating how TRPA1 channel-mediated fluxes contribute to astrocyte basal Ca(2+) levels and neuronal function via constitutive D-serine release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.