ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Association between wet-bulb globe temperature and epilepsy: a space-time-stratified case-crossover study in Taiwan.Tropical medicine and health · 2025Article
- Climate change, gut microbiome, and epilepsy-New paradigms beyond the gut-brain axis.Frontiers in neurology · 2025Article
- Voltage-gated calcium channels in genetic epilepsies.Journal of neurochemistry · 2024Review
- Review
- Natural L-type calcium channels antagonists from Chinese medicine.Chinese medicine · 2024Article
- Expanding the Phenotype of the CACNA1C-Associated Neurological Disorders in Children: Systematic Literature Review and Description of a Novel Mutation.Children (Basel, Switzerland) · 2024Review
- Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor.Translational psychiatry · 2024Article
- Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex.Frontiers in molecular neuroscience · 2024Article
- Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives.Molecules (Basel, Switzerland) · 2022Review
- TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Climate change and epilepsy: Insights from clinical and basic science studies.Epilepsy & behavior : E&B · 2021Review
- Triggering Neurotransmitters Secretion from Single Cells by X-ray Nanobeam Irradiation.Nano letters · 2020Article
- Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.Microsystems & nanoengineering · 2020Article
- Latent Sex Differences in Molecular Signaling That Underlies Excitatory Synaptic Potentiation in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain.Molecular cell · 2018Article
- Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.Neurobiology of disease · 2018Article
- The efficacy of Ranolazine on E1784K is altered by temperature and calcium.Scientific reports · 2018Article
- Danger: High Voltage-The Role of Voltage-Gated Calcium Channels in Central Nervous System Pathology.Cells · 2017Review
- Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility.Molecular neurobiology · 2017Article
- Light controls cerebral blood flow in naive animals.Nature communications · 2017Article
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7 authors at 2 institutions in 2 countries.
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Abstract
Febrile seizures are associated with increased brain temperature and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin, which are sodium channel blockers. Although they are clearly correlated with the hyperthermic condition, the precise cellular mechanisms of febrile seizures remain unclear. We performed patch-clamp recordings from pyramidal cells in acute rat brain slices at temperatures up to 40°C and found that, at ≥37°C, L-type calcium channels are active at unexpectedly hyperpolarized potentials and drive intrinsic firing, which is also supported by a temperature-dependent, gadolinium-sensitive sodium conductance. Pharmacological data, RT-PCR, and the current persistence in Cav1.3 knock-out mice suggested a critical contribution of Cav1.2 subunits to the temperature-dependent intrinsic firing, which was blocked by nimodipine. Because intrinsic firing may play a critical role in febrile seizures, we tested the effect of nimodipine in an in vivo model of febrile seizures and found that this drug dramatically reduces both the incidence and duration of febrile seizures in rat pups, suggesting new possibilities of intervention for this important pathological condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.