ArticleBiomedical optics express2013
Talbot-defocus multiscan tomography using the synchrotron X-ray microscope to study the lacuno-canalicular network in mouse bone.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment.Frontiers in bioengineering and biotechnology · 2026Review
- Hypermineralization of Hearing-Related Bones by a Specific Osteoblast Subtype.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus.Development (Cambridge, England) · 2015Article
- Strain amplification analysis of an osteocyte under static and cyclic loading: a finite element study.BioMed research international · 2015Article
- Micro- and nano-CT for the study of bone ultrastructure.Current osteoporosis reports · 2014Review
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Authors and funding
7 authors.
Funding
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Abstract
The three-dimensional network of lacunae and canaliculi that regulates metabolism in bone contains osteocytes and their dendritic processes. We constructed a synchrotron radiation X-ray microscope for sequential tomography of mouse tibia first by using a Talbot interferometer to detect the degree of bone mineralization and then by using absorption contrast under a slightly defocused setting to enhance outline contrast thereby visualizing structures of the osteocyte lacuno-canalicular network. The resultant pair of tomograms was precisely aligned with each other, allowing evaluation of mineral density in the vicinity of each osteocyte lacuna and canaliculus over the entire thickness of the cortical bone. Thus, multiscan microscopic X-ray tomography is a powerful tool for analyzing bone mineralization in relation to the lacuno-canalicular network at the submicron resolution level.
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