Evidence map›Paper›PMID 23761845›Full record

ArticleBiomedical optics express2013

Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography.

Hansford C Hendargo, Rolando Estrada, Stephanie J Chiu, Carlo Tomasi, Sina Farsiu, Joseph A Izatt

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 139 citations in OpenAlex.

  1. Volumetric montaging of optical coherence tomography in human retinas.bioRxiv : the preprint server for biology · 2026
    Article
  2. Strip-Scanning for Efficient Widefield Retinal OCTA Mosaicking.Translational vision science & technology · 2026
    Article
  3. Widefield OCT angiography.Progress in retinal and eye research · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Non-Rigid Registration for High-Resolution Retinal Imaging.Diagnostics (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Artificial intelligence in OCT angiography.Progress in retinal and eye research · 2021
    Review
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hansford C HendargoDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Rolando Estrada
Stephanie J Chiu
Carlo Tomasi
Sina Farsiu
Joseph A Izatt
Duke University · US

Funding

Ophthalmic Imaging Using Adaptive Optics and OCTR01EY014743 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI WERNER, JOHN S · 2003 to 2012
$10.4M
Intraoperative OCT Guidance of Intraocular SurgeryR01EY023039 · NEI · DUKE UNIVERSITY · PI IZATT, JOSEPH A, TOTH, CYNTHIA ANN · 2013 to 2016
$3.9M
Computer Aided Classification of Diabetic Macular EdemaR01EY022691 · NEI · DUKE UNIVERSITY · PI FARSIU, SINA · 2012 to 2016
$1.9M
Portable Motion Compensated SDOCT System for Imaging Young ChildrenR21EY021321 · NEI · DUKE UNIVERSITY · PI FARSIU, SINA, IZATT, JOSEPH A · 2012 to 2013
$404k
NEI NIH HHS R01 EY014743NEI NIH HHS R01 EY022691NEI NIH HHS R01 EY023039NEI NIH HHS R21 EY021321
6 · The paper itself

Abstract

Variance processing methods in Fourier domain optical coherence tomography (FD-OCT) have enabled depth-resolved visualization of the capillary beds in the retina due to the development of imaging systems capable of acquiring A-scan data in the 100 kHz regime. However, acquisition of volumetric variance data sets still requires several seconds of acquisition time, even with high speed systems. Movement of the subject during this time span is sufficient to corrupt visualization of the vasculature. We demonstrate a method to eliminate motion artifacts in speckle variance FD-OCT images of the retinal vasculature by creating a composite image from multiple volumes of data acquired sequentially. Slight changes in the orientation of the subject's eye relative to the optical system between acquired volumes may result in non-rigid warping of the image. Thus, we use a B-spline based free form deformation method to automatically register variance images from multiple volumes to obtain a motion-free composite image of the retinal vessels. We extend this technique to automatically mosaic individual vascular images into a widefield image of the retinal vasculature.

Indexed as

(100.2980) Image enhancement(170.4470) Ophthalmology(170.4500) Optical coherence tomography

Identifiers

PMID23761845
PMCPMC3675861
OpenAlexW1969664442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.