ArticleFrontiers in neurology2013
The serendipity case of the pedunculopontine nucleus low-frequency brain stimulation: chasing a gait response, finding sleep, and cognition improvement.
Article in Frontiers in neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Impact of simultaneous subthalamic and nigral stimulation on dysphagia in Parkinson's disease.Annals of clinical and translational neurology · 2020Trial
- The effects of deep brain stimulation on sleep: a systematic review and meta-analysis.Sleep advances : a journal of the Sleep Research Society · 2024Review
- The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics.Translational psychiatry · 2023Review
- In vivo structural connectome of arousal and motor brainstem nuclei by 7 Tesla and 3 Tesla MRI.Human brain mapping · 2022Article
- The Association Between Gait Speed and Sleep Problems Among Chinese Adults Aged 50 and Greater.Frontiers in neuroscience · 2022Article
- Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson's Disease.Frontiers in human neuroscience · 2020Article
- Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology.Frontiers in human neuroscience · 2020Article
- Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.Journal of neuroscience research · 2019Review
- Bottom-up gamma maintenance in various disorders.Neurobiology of disease · 2019Review
- The pedunclopontine nucleus and Parkinson's disease.Neurobiology of disease · 2019Review
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human.Frontiers in neuroscience · 2017Review
- The pedunculopontine tegmental nucleus-A functional hypothesis from the comparative literature.Movement disorders : official journal of the Movement Disorder Society · 2016Review
- Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus (PPN) Influences Visual Contrast Sensitivity in Human Observers.PloS one · 2016Article
- Arousal and the control of perception and movement.Current trends in neurology · 2016Article
- Pedunculopontine arousal system physiology - Deep brain stimulation (DBS).Sleep science (Sao Paulo, Brazil) · 2015Review
- Neurostimulation to improve level of consciousness in patients with epilepsy.Neurosurgical focus · 2015Review
- The integrative role of the pedunculopontine nucleus in human gait.Brain : a journal of neurology · 2015Article
- Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The physiology of the pedunculopontine nucleus: implications for deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficacious therapy for Parkinson's disease (PD) but its effects on non-motor facets may be detrimental. The low-frequency stimulation (LFS) of the pedunculopontine nucleus (PPN or the nucleus tegmenti pedunculopontini - PPTg-) opened new perspectives. In our hands, PPTg-LFS revealed a modest influence on gait but increased sleep quality and degree of attentiveness. At odds with potential adverse events following STN-DBS, executive functions, under PPTg-ON, ameliorated. A recent study comparing both targets found that only PPTg-LFS improved night-time sleep and daytime sleepiness. Chances are that different neurosurgical groups influence either the PPN sub-portion identified as pars dissipata (more interconnected with GPi/STN) or the caudal PPN region known as pars compacta, preferentially targeting intralaminar and associative nucleus of the thalamus. Yet, the wide electrical field delivered affects a plethora of en passant circuits, and a fine distinction on the specific pathways involved is elusive. This review explores our angle of vision, by which PPTg-LFS activates cholinergic and glutamatergic ascending fibers, influencing non-motor behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.