ArticleJournal of neurophysiology2013
Modular control of varied locomotor tasks in children with incomplete spinal cord injuries.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of the Scientific Literature for Rehabilitation/Habilitation Among Individuals With Pediatric-Onset Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2022Pooled it
- Walking speed is not the best outcome to evaluate the effect of robotic assisted gait training in people with motor incomplete Spinal Cord Injury: A Systematic Review with meta-analysis.The journal of spinal cord medicine · 2019Pooled it
- Kinematic and Neuromuscular Adaptations in Incomplete Spinal Cord Injury after High- versus Low-Intensity Locomotor Training.Journal of neurotrauma · 2019Trial
- Effects of spinal transection and locomotor speed on muscle synergies of the cat hindlimb.The Journal of physiology · 2025Article
- Age-related differences in the modulation of muscle coordination complexity for goal-directed lateral stepping.Journal of biomechanics · 2025Article
- Generalizability of motor modules across walking-based and in-place tasks - a distribution-based analysis on total knee replacement patients.Frontiers in bioengineering and biotechnology · 2025Article
- Multi-session adaptation to audiovisual and sensorimotor biofeedback is heterogeneous among adolescents with cerebral palsy.PloS one · 2024Article
- Motor control complexity can be dynamically simplified during gait pattern exploration using motor control-based biofeedback.Journal of neurophysiology · 2023Article
- Recent developments in muscle synergy analysis in young people with neurodevelopmental diseases: A Systematic Review.Frontiers in bioengineering and biotechnology · 2023Review
- Evidence for shared neural information between muscle synergies and corticospinal efficacy.Scientific reports · 2022Article
- Temporal Synergies Detection in Gait Cyclograms Using Wearable Technology.Sensors (Basel, Switzerland) · 2022Article
- Synergies are minimally affected during emulation of cerebral palsy gait patterns.Journal of biomechanics · 2022Article
- Modular organization of locomotor networks in people with severe spinal cord injury.Frontiers in neuroscience · 2022Article
- Patient-specific functional electrical stimulation strategy based on muscle synergy and walking posture analysis for gait rehabilitation of stroke patients.The Journal of international medical research · 2021Article
- Generalization of motor module recruitment across standing reactive balance and walking is associated with beam walking performance in young adults.Gait & posture · 2020Article
- Reorganization of motor modules for standing reactive balance recovery following pyridoxine-induced large-fiber peripheral sensory neuropathy in cats.Journal of neurophysiology · 2020Article
- Motor module generalization across balance and walking is impaired after stroke.Journal of neurophysiology · 2019Article
- Can altered muscle synergies control unimpaired gait?Journal of biomechanics · 2019Article
- Motor primitives are determined in early development and are then robustly conserved into adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Muscle synergies demonstrate only minimal changes after treatment in cerebral palsy.Journal of neuroengineering and rehabilitation · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A module is a functional unit of the nervous system that specifies functionally relevant patterns of muscle activation. In adults, four to five modules account for muscle activation during walking. Neurological injury alters modular control and is associated with walking impairments. The effect of neurological injury on modular control in children is unknown and may differ from adults due to their immature and developing nervous systems. We examined modular control of locomotor tasks in children with incomplete spinal cord injuries (ISCIs) and control children. Five controls (8.6 ± 2.7 yr of age) and five children with ISCIs (8.6 ± 3.7 yr of age performed treadmill walking, overground walking, pedaling, supine lower extremity flexion/extension, stair climbing, and crawling. Electromyograms (EMGs) were recorded in bilateral leg muscles. Nonnegative matrix factorization was applied, and the minimum number of modules required to achieve 90% of the "variance accounted for" (VAF) was calculated. On average, 3.5 modules explained muscle activation in the controls, whereas 2.4 modules were required in the children with ISCIs. To determine if control is similar across tasks, the module weightings identified from treadmill walking were used to reconstruct the EMGs from each of the other tasks. This resulted in VAF values exceeding 86% for each child and each locomotor task. Our results suggest that 1) modularity is constrained in children with ISCIs and 2) for each child, similar neural control mechanisms are used across locomotor tasks. These findings suggest that interventions that activate the neuromuscular system to enhance walking also may influence the control of other locomotor tasks.
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