ArticleNeurology2013
Prospective study of restless legs syndrome and mortality among men.
Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Shared underlying dynamics between sleep disorder and psychiatric disorder: proinflammatory state?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Prevalence of Current Restless Legs Syndrome Symptoms Among Patients Treated with Buprenorphine/Naloxone for Opioid Use Disorder.Nature and science of sleep · 2023Article
- Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- High national rates of high-dose dopamine agonist prescribing for restless legs syndrome.Sleep · 2022Article
- Treating Restless Legs Syndrome Was Associated With Low Risk of Cardiovascular Disease: A Cohort Study With 3.4 Years of Follow-Up.Journal of the American Heart Association · 2021Article
- Effectiveness and safety of massage in the treatment of restless legs syndrome: A protocol for systematic review and meta analysis.Medicine · 2020Article
- Prevalence and Risk Factors of Restless Legs Syndrome in Hemodialysis Patients.Nature and science of sleep · 2020Article
- Blood pressure profile and endothelial function in restless legs syndrome.Scientific reports · 2019Article
- Increased Risk for New-Onset Psychiatric Adverse Events in Patients With Newly Diagnosed Primary Restless Legs Syndrome Who Initiate Treatment With Dopamine Agonists: A Large-Scale Retrospective Claims Matched-Cohort Analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Association of Restless Legs Syndrome With Risk of Suicide and Self-harm.JAMA network open · 2019Article
- Restless arms syndrome: prevalence, impact, and management strategies.Neuropsychiatric disease and treatment · 2019Review
- Sleep Disorders and Attention Deficit: A Consequence of Proinflammatory State?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Prospective study of restless legs syndrome and total and cardiovascular mortality among women.Neurology · 2018Article
- Sleep Disturbances as a Risk Factor for Stroke.Journal of stroke · 2018Review
- Restless legs syndrome in maintenance hemodialysis patients: an epidemiologic survey in Hefei.International urology and nephrology · 2017Article
- Plasma apelin level in patients with restless legs syndrome and its association with periodic leg movements.Sleep & breathing = Schlaf & Atmung · 2017Article
- Prevalence of restless legs syndrome during detoxification from alcohol and opioids.Journal of substance abuse treatment · 2017Observational
- Prognostic value of restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis.Neuropsychiatric disease and treatment · 2017Article
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo prospectively examine whether men with restless legs syndrome (RLS) had an increased risk of mortality.
methodThis was a prospective cohort study of 18,425 US men free of diabetes, arthritis, and renal failure in the Health Professionals Follow-up Study (HPFS). In 2002, RLS was assessed using a set of standardized questions. Deaths were identified from state vital statistics records, the National Death Index, family reports, and the postal system.
resultsDuring 8 years of follow-up (2002-2010), we documented 2,765 deaths. In an age-adjusted model, RLS was associated with a 39% increased risk of mortality (hazard ratio [HR] = 1.39; 95% confidence interval [CI] 1.19-1.62; p < 0.0001). The association between RLS and mortality was slightly attenuated after further adjustment for body mass index, lifestyle factors, chronic conditions, sleep duration, and other sleep-related disorders (adjusted HR = 1.30; 95% CI 1.11-1.52; p = 0.003). When we further excluded those with major chronic conditions (e.g., cancer, high blood pressure, cardiovascular disease, and other comorbidities), the adjusted HR was 1.92 (95% CI 1.03-3.56; p = 0.04). The interactions between RLS and other risk factors (older age, overweight, short sleep duration, smoking, low physical activity, and unhealthy diet) in relation to total mortality risk were not significant (p for interaction >0.2 for all).
conclusionWe observed that men with RLS had a higher overall mortality and this association was independent of known risk factors. The increased mortality in RLS was more frequently associated with respiratory disease, endocrine disease, nutritional/metabolic disease, and immunologic disorders. Future research exploring the pathophysiologic relationship between these disorders and RLS is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.