ArticleNucleic acids research2013
The genome of Anopheles darlingi, the main neotropical malaria vector.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed, 156 citations in OpenAlex.
- Metabolic reprogramming and gut microbiota ecology drive divergent Plasmodium vivax infection outcomes in Anopheles darlingi.PLoS pathogens · 2025Article
- De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription.BMC genomics · 2025Article
- Genome-wide cataloging and orthology analysis of long noncoding RNA expression in three species of Anopheles mosquito.BMC genomics · 2025Article
- Two chromosomal reference genome sequences for the malaria mosquito,Wellcome open research · 2025Article
- The molecular toll pathway repertoire in anopheline mosquitoes.Developmental and comparative immunology · 2025Article
- The Molecular Toll Pathway Repertoire in Anopheline Mosquitoes.bioRxiv : the preprint server for biology · 2024Article
- Unravelling the genome of the brackish water malaria vector Anopheles aquasalis.Scientific reports · 2023Article
- Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors.eLife · 2022Article
- High-resolution species assignment ofeLife · 2022Article
- Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil.The American journal of tropical medicine and hygiene · 2022Article
- Genome-wide identification and expression profiling of odorant receptor genes in the malaria vector Anopheles sinensis.Parasites & vectors · 2022Article
- Molecular and functional characterization of a conserved odorant receptor from Aedes albopictus.Parasites & vectors · 2022Article
- Functional Constraints on Insect Immune System Components Govern Their Evolutionary Trajectories.Molecular biology and evolution · 2022Article
- Phylogenetic relationships of the supercontig of sodium channel subunit I (NaV) in 17 species of Anopheles (Diptera: Culicidae).Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Transposable element variants and their potential adaptive impact in urban populations of the malaria vectorGenome research · 2022Article
- Susceptibility of Field-CollectedGenes · 2021Article
- How will mosquitoes adapt to climate warming?eLife · 2021Article
- Advances and opportunities in malaria population genomics.Nature reviews. Genetics · 2021Review
- Human blood microRNA hsa-miR-21-5p induces vitellogenin in the mosquito Aedes aegypti.Communications biology · 2021Article
- Physical Mapping of theInsects · 2021Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
69 authors at 15 institutions in 3 countries.
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Abstract
Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector-human and vector-parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi.
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