ArticleJournal of clinical microbiology2013
Preliminary laboratory report of fungal infections associated with contaminated methylprednisolone injections.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Clinical Characteristics, Health Care Utilization, and Outcomes Among Patients in a Pilot Surveillance System for Invasive Mold Disease-Georgia, United States, 2017-2019.Open forum infectious diseases · 2022Article
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- Molecular Techniques for Genus and Species Determination of Fungi From Fresh and Paraffin-Embedded Formalin-Fixed Tissue in the Revised EORTC/MSGERC Definitions of Invasive Fungal Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Long-term Outcomes of Patients With Fungal Infections Associated With Contaminated Methylprednisolone Injections.Open forum infectious diseases · 2020Article
- Rhizopus microsporus Infections Associated with Surgical Procedures, Argentina, 2006-2014.Emerging infectious diseases · 2020Article
- Necrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient.Pediatric transplantation · 2018Article
- Two cases of fungal keratitis caused byMedical mycology case reports · 2018Article
- Healthcare-associated fungal outbreaks: New and uncommon species, New molecular tools for investigation and prevention.Antimicrobial resistance and infection control · 2018Review
- Isolation and identification of culturable fungi from the genitals and semen of healthy giant pandas (Ailuropoda melanoleuca).BMC veterinary research · 2017Article
- A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases.Open forum infectious diseases · 2017Article
- Development of a Multilocus Sequence Typing System for Medically Relevant Bipolaris Species.Journal of clinical microbiology · 2015Article
- In Vitro Activities of Eight Antifungal Drugs against a Global Collection of Genotyped Exserohilum Isolates.Antimicrobial agents and chemotherapy · 2015Article
- In vitro study of the variable effects of proton pump inhibitors on voriconazole.Antimicrobial agents and chemotherapy · 2015Article
- Utility of real-time PCR for detection of Exserohilum rostratum in body and tissue fluids during the multistate outbreak of fungal meningitis and other infections.Journal of clinical microbiology · 2015Article
- Outbreak of fungal infections associated with contaminated methylprednisolone acetate: an update.Current infectious disease reports · 2015Article
- Black Molds and Melanized Yeasts Pathogenic to Humans.Cold Spring Harbor perspectives in medicine · 2014Review
- Fungi associated with drug recalls and rare disease outbreaks.Journal of industrial microbiology & biotechnology · 2014Review
- Whole-genome analysis of Exserohilum rostratum from an outbreak of fungal meningitis and other infections.Journal of clinical microbiology · 2014Article
- Molecular and nonmolecular diagnostic methods for invasive fungal infections.Clinical microbiology reviews · 2014Review
- Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In September 2012, the Centers for Disease Control and Prevention (CDC) initiated an outbreak investigation of fungal infections linked to injection of contaminated methylprednisolone acetate (MPA). Between 2 October 2012 and 14 February 2013, the CDC laboratory received 799 fungal isolates or human specimens, including cerebrospinal fluid (CSF), synovial fluid, and abscess tissue, from 469 case patients in 19 states. A novel broad-range PCR assay and DNA sequencing were used to evaluate these specimens. Although Aspergillus fumigatus was recovered from the index case, Exserohilum rostratum was the primary pathogen in this outbreak and was also confirmed from unopened MPA vials. Exserohilum rostratum was detected or confirmed in 191 specimens or isolates from 150 case patients, primarily from Michigan (n=67 patients), Tennessee (n=26), Virginia (n=20), and Indiana (n=16). Positive specimens from Michigan were primarily abscess tissues, while positive specimens from Tennessee, Virginia, and Indiana were primarily CSF. E. rostratum antifungal susceptibility MIC50 and MIC90 values were determined for voriconazole (1 and 2 μg/ml, respectively), itraconazole (0.5 and 1 μg/ml), posaconazole (0.5 and 1 μg/ml), isavuconazole (4 and 4 μg/ml), and amphotericin B (0.25 and 0.5 μg/ml). Thirteen other mold species were identified among case patients, and four other fungal genera were isolated from the implicated MPA vials. The clinical significance of these other fungal species remains under investigation. The laboratory response provided significant support to case confirmation, enabled linkage between clinical isolates and injected vials of MPA, and described significant features of the fungal agents involved in this large multistate outbreak.
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