Evidence map›Paper›PMID 23761107›Full record

ReviewStem cells translational medicine2013

Concise review: endothelial stem and progenitor cells and their habitats.

Michael S Goligorsky, Petri Salven

Open access · goldAbstract readReview
In one paragraph

Review in Stem cells translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Isolation of endothelial progenitor cells from human adipose tissue.International journal of obesity (2005) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Efficacy of Autologous Bone Marrow Mononuclear Cell Transplantation Therapy for Type 2 Diabetes Mellitus: An Updated Meta-Analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Michael S GoligorskyDepartment of Medicine, New York Medical College, Valhalla, NY, USA. michael_goligorsky@nymc.edu
Petri Salven
New York Medical College · USUniversity of Helsinki · FI

Funding

RENAL ENDOTHELIAL AND SMOOTH MUSCLE CELLS INTERACTIONSR01DK045462 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1995 to 2014
$4.8M
VASCULAR PERMEABILITY IN DIABETIC NEPHROPATHYR01DK054602 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1999 to 2010
$2.5M
Endothelial dysfunction in acute renal ischemiaR01DK052783 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1997 to 2007
$2.0M
NIDDK NIH HHS DK052783NIDDK NIH HHS DK45462NIDDK NIH HHS DK54602NIDDK NIH HHS R01 DK045462NIDDK NIH HHS R01 DK052783NIDDK NIH HHS R01 DK054602
6 · The paper itself

Abstract

Recent studies on the stem cell origins of regenerating tissues have provided solid evidence in support of the role of the resident cells, rather than bone marrow-derived or transplanted stem cells, in restoring tissue architecture after an injury. This is also true for endothelial stem and progenitor cells: local pools exist in the vascular wall, and those cells are the primary drivers of vascular regeneration. This paradigm shift offers an opportunity to rethink and refine our understanding of the multiple therapeutic effects of transplanted endothelial progenitor cells, focusing on their secretome, sheddome, intercellular communicational routes, and other potential ways to rejuvenate and replenish the pool of resident cells. The dynamics of vascular wall resident cells, at least in the adipose tissue, may shed light on the origins of other cells present in the vascular wall-pericytes and mesenchymal stem cells. The fate of these cells in aging and disease awaits elucidation.

Indexed as

AnimalsCellular MicroenvironmentEndothelial CellsHumansMesenchymal Stem CellsPericytesRegenerationEndothelial cellProgenitor cellsStem cellsVascular development

Identifiers

PMID23761107
PMCPMC3697817
OpenAlexW2109223404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.