ArticleMolecular biology of the cell2013
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- SIRT7: the seventh key to unlocking the mystery of aging.Physiological reviews · 2024Review
- Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.iScience · 2023Article
- Magnesium and Liver Metabolism Through the Lifespan.Advances in nutrition (Bethesda, Md.) · 2023Review
- HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration.Nucleic acids research · 2020Article
- Epigenetic changes during aging and their reprogramming potential.Critical reviews in biochemistry and molecular biology · 2019Review
- High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase inThe Journal of biological chemistry · 2018Article
- Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7.Frontiers in endocrinology · 2018Review
- Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders.Neurochemical research · 2017Review
- Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Changes in human sirtuin 6 gene promoter methylation during aging.Biomedical reports · 2014Article
- Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver.BMC endocrine disorders · 2014Article
- Changes in liver cell DNA methylation status in diabetic mice affect its FT-IR characteristics.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperglycemia, like aging, induces chromatin remodeling in mouse hepatocytes in comparison to normoglycemia and younger age, respectively. Changes in glucose metabolism also affect the action and expression of sirtuins, promoting changes in chromatin conformation and dynamics. Here we investigate the abundance and activity of the nuclear sirtuins Sirt1, Sirt6, and Sirt7 in mouse hepatocytes in association with specific histone acetylation, DNA damage, and the activation of nucleolar organizing regions (NORs) in hyperglycemic nonobese diabetic (NOD) and old normoglycemic BALB/c mouse strains. Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair. With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation are found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia. Therefore understanding the regulation of epigenetic factors in diabetes and aging is crucial for the development of new therapeutic approaches that could prevent diseases and improve quality of life.
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