ArticleCytotechnology2014
Amelioration of cisplatin-induced nephrotoxicity by grape seed extract and fish oil is mediated by lowering oxidative stress and DNA damage.
Article in Cytotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- The effect of short-term vitamin D on the antioxidant capacity following exhaustive aerobic exercise.African health sciences · 2023Trial
- Proanthocyanidins Attenuate Cisplatin-Induced Acute Kidney Injury and are Associated With Reshaping Gut Microbiota and Restoring Redox Homeostasis.Molecular nutrition & food research · 2026Article
- Pre- and post-treatment effects of date fruit phenolics in cisplatin-induced hepatotoxicity.Toxicology reports · 2025Article
- Grape Seed Components as Protectors of Inflammation, DNA Damage, and Cancer.Current nutrition reports · 2023Review
- The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin.Scientific reports · 2022Article
- A comparative study among dietary supplementations of antibiotic, grape seed and chamomile oils on growth performance and carcass properties of growing rabbits.Saudi journal of biological sciences · 2022Article
- Impacts of Heat Stress on Rabbit Immune Function, Endocrine, Blood Biochemical Changes, Antioxidant Capacity and Production Performance, and the Potential Mitigation Strategies of Nutritional Intervention.Frontiers in veterinary science · 2022Review
- Article
- Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity.Antioxidants (Basel, Switzerland) · 2021Article
- The AntioxidantAntioxidants (Basel, Switzerland) · 2021Article
- Cisplatin chemotherapy and renal function.Advances in cancer research · 2021Review
- Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism.Molecules (Basel, Switzerland) · 2020Article
- The ameliorative effects of ceftriaxone and vitamin E against cisplatin-induced nephrotoxicity.Environmental science and pollution research international · 2019Article
- GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney.Oncotarget · 2017Article
- Nephroprotective efficacy of ceftriaxone against cisplatin-induced subchronic renal fibrosis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- The in vitro protective effect of salicylic acid against paclitaxel and cisplatin-induced neurotoxicity.Cytotechnology · 2016Article
- Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats.Cytotechnology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cisplatin (CP) is a chemotherapeutic drug used in treatment of malignancies. However, its clinical utility is limited by nephrotoxicity. The purpose of the present study was to investigate the protective role of grape seed proanthocyanidin extract (GSPE) (100 mg/kg/day) or fish oil (FO) (5 ml/kg/day) against cisplatin induced nephrotoxicity in terms of biochemical parameters, oxidative stress and DNA damage. CP nephrotoxiciy is manifested by increased levels of serum creatinine, urea and uric acid, accompanied by their decrease in urine. Na, K and Ca levels were altered in both serum and urine. In addition, cisplatin caused a decrease in renal GSH, SH-group, SOD, GST, and Na-K-ATPase levels. However the levels of MDA, H2O2 and NO were increased. Also, we assessed the renal genotoxic potential of cisplatin as manifested by an increase in the tail length of DNA, tail intensity (DNA %) and tail moment. On the other hand, administration of GSPE or FO pre-cisplatin treatment ameliorated the current changes in most of the above tested parameters, particularly oxidative stress, endogenous antioxidant defense system and DNA damage indicating their curative effect. Thus, it can be concluded that the consumption of GSPE or FO might be useful for preventing nephrotoxicity caused by cisplatin treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.