ReviewPediatric nephrology (Berlin, Germany)2014
Metabolic syndrome in children with chronic kidney disease and after renal transplantation.
Review in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Relation between obesity-related comorbidities and kidney function estimation in children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Malnutrition and immune cell subsets in children undergoing kidney transplantation.Pediatric transplantation · 2022Article
- Left ventricular stiffness in paediatric patients with end-stage kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Depression and neurocognitive dysfunction in pediatric and young adult chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Article
- Non-immunologic allograft loss in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2019Review
- Cardiometabolic Risk Factors, Metabolic Syndrome, and Chronic Kidney Disease Progression in Children.The Journal of pediatrics · 2018Article
- Hypertension in pediatric patients with chronic kidney disease: management challenges.International journal of nephrology and renovascular disease · 2017Review
- Long-term effects of paediatric kidney transplantation.Nature reviews. Nephrology · 2016Review
- Paediatric obesity and renal transplantation: current challenges and solutions.Pediatric nephrology (Berlin, Germany) · 2016Review
- Paediatrics, insulin resistance and the kidney.Pediatric nephrology (Berlin, Germany) · 2015Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral obesity and metabolic abnormalities typical for metabolic syndrome (MS) are the new epidemic in adolescence. MS is not only the risk factor for cardiovascular disease but also for chronic kidney disease (CKD). Thus, there are some reasons to recognize MS as a new challenge for pediatric nephrologists. First, hypertensive and diabetic nephropathy, the main causes of CKD in adults, both share the same pathophysiological abnormalities associated with visceral obesity and insulin resistance and have their origins in childhood. Secondly, as the obesity epidemic also affects children with CKD, MS emerges as the risk factor for progression of CKD. Thirdly, metabolic abnormalities typical for MS may pose additional risk for cardiovascular morbidity and mortality in children with CKD. Finally, although the renal transplantation reverses uremic abnormalities it is associated with an exposure to new metabolic risk factors typical for MS and MS has been found to be the risk factor for graft loss and cardiovascular morbidity after renal transplantation. MS is the result of imbalance between dietary energy intake and expenditure inducing disproportionate fat accumulation. Thus, the best prevention and treatment of MS is physical activity and maintenance of proper relationship between lean and fat mass.
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