ArticleDevelopment (Cambridge, England)2013
RNA-directed DNA methylation regulates parental genomic imprinting at several loci in Arabidopsis.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 96 citations in OpenAlex.
- Molecular characterization of capulet2 reveals the importance of ANAPHASE PROMOTING COMPLEX 6 maternal expression in endosperm development.Plant physiology · 2026Article
- Integrated methylome and transcriptome analysis provides insight into DNA methylation-mediated networks in sexual dimorphism of Vernicia montana.BMC plant biology · 2026Article
- Integrative Analysis of Omics Reveals RdDM Pathway Participation in the Initiation of Rice Microspore Embryogenesis Under Cold Treatment.Plants (Basel, Switzerland) · 2025Article
- Parental dialectic: Epigenetic conversations in endosperm.Current opinion in plant biology · 2024Review
- Upstream regulator of genomic imprinting in rice endosperm is a small RNA-associated chromatin remodeler.Nature communications · 2024Article
- Imprinting but not cytonuclear interactions determines seed size heterosis in Arabidopsis hybrids.Plant physiology · 2024Article
- Small RNA-mediated DNA methylation during plant reproduction.The Plant cell · 2023Review
- Spatial and temporal regulation of parent-of-origin allelic expression in the endosperm.Plant physiology · 2023Article
- Canalization of genome-wide transcriptional activity in Arabidopsis thaliana accessions by MET1-dependent CG methylation.Genome biology · 2022Article
- RNA Pol IV induces antagonistic parent-of-origin effects on Arabidopsis endosperm.PLoS biology · 2022Article
- Bypassing reproductive barriers in hybrid seeds using chemically induced epimutagenesis.The Plant cell · 2022Article
- Regulation of DNA Methylation During Plant Endosperm Development.Frontiers in genetics · 2022Review
- Article
- Divergence among rice cultivars reveals roles for transposition and epimutation in ongoing evolution of genomic imprinting.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis.Nucleic acids research · 2021Article
- Loss of Small-RNA-Directed DNA Methylation in the Plant Cell Cycle Promotes Germline Reprogramming and Somaclonal Variation.Current biology : CB · 2021Article
- License to Regulate: Noncoding RNA Special Agents in Plant Meiosis and Reproduction.Frontiers in plant science · 2021Review
- Dynamics of DNA Methylation and Its Functions in Plant Growth and Development.Frontiers in plant science · 2021Review
- RNA-directed DNA Methylation.PLoS genetics · 2020Article
- MethGET: web-based bioinformatics software for correlating genome-wide DNA methylation and gene expression.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
In mammals and plants, parental genomic imprinting restricts the expression of specific loci to one parental allele. Imprinting in mammals relies on sex-dependent de novo deposition of DNA methylation during gametogenesis but a comparable mechanism was not shown in plants. Rather, paternal silencing by the maintenance DNA methyltransferase 1 (MET1) and maternal activation by the DNA demethylase DEMETER (DME) cause maternal expression. However, genome-wide studies suggested other DNA methylation-dependent imprinting mechanisms. Here, we show that de novo RNA-directed DNA methylation (RdDM) regulates imprinting at specific loci expressed in endosperm. RdDM in somatic tissues is required to silence expression of the paternal allele. By contrast, the repression of RdDM in female gametes participates with or without DME requirement in the activation of the maternal allele. The contrasted activity of DNA methylation between male and female gametes appears sufficient to prime imprinted maternal expression. After fertilization, MET1 maintains differential expression between the parental alleles. RdDM depends on small interfering RNAs (siRNAs). The involvement of RdDM in imprinting supports the idea that sources of siRNAs such as transposons and de novo DNA methylation were recruited in a convergent manner in plants and mammals in the evolutionary process leading to selection of imprinted loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.