ArticleDevelopment (Cambridge, England)2013
Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- The origin and evolution of dorsal determination mechanisms in vertebrate paired appendages.Current biology : CB · 2026Article
- A mathematical model of human oesophageal motility function.Royal Society open science · 2025Article
- Co-option of neck muscles supported the vertebrate water-to-land transition.Nature communications · 2024Article
- Multiple embryonic sources converge to form the pectoral girdle skeleton in zebrafish.Nature communications · 2024Article
- Characteristics ofInternational journal of molecular sciences · 2023Article
- Article
- Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models.Scientific reports · 2022Article
- The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Mutations in MYLPF Cause a Novel Segmental Amyoplasia that Manifests as Distal Arthrogryposis.American journal of human genetics · 2020Article
- Cetacean Orbital Muscles: Anatomy and Function of the Circular Layers.Anatomical record (Hoboken, N.J. : 2007) · 2020Article
- Anterior trunk muscle shows mix of axial and appendicular developmental patterns.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Muscle precursor cell movements in zebrafish are dynamic and require Six family genes.Development (Cambridge, England) · 2019Article
- The Application of Methylprednisolone Nanoscale Zirconium-Porphyrin Metal-Organic Framework (MPS-NPMOF) in the Treatment of Photoreceptor Degeneration.International journal of nanomedicine · 2019Article
- The zebrafish HGF receptor met controls migration of myogenic progenitor cells in appendicular development.PloS one · 2019Article
- Myogenin promotes myocyte fusion to balance fibre number and size.Nature communications · 2018Article
- Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.Developmental biology · 2017Article
- Role of branchiomotor neurons in controlling food intake of zebrafish larvae.Journal of neurogenetics · 2017Article
- Characterization of pax3a and pax3b genes in artificially induced polyploid and gynogenetic olive flounder (Paralichthys olivaceus) during embryogenesis.Fish physiology and biochemistry · 2017Article
- Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair.Disease models & mechanisms · 2016Article
- Embracing change: striated-for-smooth muscle replacement in esophagus development.Skeletal muscle · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Striated muscles that enable mouth opening and swallowing during feeding are essential for efficient energy acquisition, and are likely to have played a fundamental role in the success of early jawed vertebrates. The developmental origins and genetic requirements of these muscles are uncertain. Here, we determine by indelible lineage tracing in mouse that fibres of sternohyoid muscle (SHM), which is essential for mouth opening during feeding, and oesophageal striated muscle (OSM), which is crucial for voluntary swallowing, arise from Pax3-expressing somite cells. In vivo Kaede lineage tracing in zebrafish reveals the migratory route of cells from the anteriormost somites to OSM and SHM destinations. Expression of pax3b, a zebrafish duplicate of Pax3, is restricted to the hypaxial region of anterior somites that generate migratory muscle precursors (MMPs), suggesting that Pax3b plays a role in generating OSM and SHM. Indeed, loss of pax3b function led to defective MMP migration and OSM formation, disorganised SHM differentiation, and inefficient ingestion and swallowing of microspheres. Together, our data demonstrate Pax3-expressing somite cells as a source of OSM and SHM fibres, and highlight a conserved role of Pax3 genes in the genesis of these feeding muscles of vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.