ArticleOncology letters2013
Dying endothelial cells stimulate proliferation of malignant glioma cells via a caspase 3-mediated pathway.
Article in Oncology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Apoptotic cells promote circulating tumor cell survival and metastasis.Communications biology · 2025Article
- Primordial Follicle Survival and Changes in Ovarian Vasculature May Be Independently Regulated During Chemotherapy.Endocrinology · 2025Article
- Understanding the molecular mechanism of regeneration through apoptosis-induced compensatory proliferation studies - updates and future aspects.Apoptosis : an international journal on programmed cell death · 2024Review
- Redox Biomarkers and Matrix Remodeling Molecules in Ovarian Cancer.Antioxidants (Basel, Switzerland) · 2024Article
- Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation.Developmental cell · 2023Article
- Review
- Increased Apoptotic Activity in Low-Risk Myelodysplastic Syndrome.Journal of clinical medicine · 2022Article
- Apoptosis - Fueling the oncogenic fire.The FEBS journal · 2021Review
- Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis.Cancers · 2021Article
- Review
- Two Sides of the Same Coin - Compensatory Proliferation in Regeneration and Cancer.Advances in experimental medicine and biology · 2019Review
- An unexpected friend - ROS in apoptosis-induced compensatory proliferation: Implications for regeneration and cancer.Seminars in cell & developmental biology · 2018Review
- Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells.BMC cell biology · 2018Article
- Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis.The Journal of biological chemistry · 2018Article
- A matter of life and death: stem cell survival in tissue regeneration and tumour formation.Nature reviews. Cancer · 2018Review
- Exploitation of Apoptotic Regulation in Cancer.Frontiers in immunology · 2018Review
- Caspase-3 expression in tumorigenesis and prognosis of buccal mucosa squamous cell carcinoma.Oncotarget · 2017Article
- Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease.Cell death and differentiation · 2017Review
- Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome.International journal of molecular sciences · 2017Review
- Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway.OncoTargets and therapy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence has indicated that apoptotic cells have a compensatory effect on the proliferation of neighboring cells. However, the potential role of dying vascular endothelial cells (ECs) in glioma tumor proliferation remains unclear. In the present study, three glioma cell lines were cocultured with dying ECs under various conditions to evaluate the effect of dying ECs on tumor proliferation using alamarBlue and trypan blue assays to assess cell proliferation and viability, respectively. The results suggested that dying ECs had a marked ability to facilitate glioma cell growth via a caspase 3-mediated pathway. Furthermore, calcium-independent phospholipase A
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.