ArticleDrugs in R&D2013
Risk of falling and hypnotic drugs: retrospective study of inpatients.
Article in Drugs in R&D, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A novel multistep approach to standardize the reported risk factors for in-hospital falls: a proof-of-concept study.Frontiers in public health · 2024Pooled it
- The Prevalence of Falls Among Older Adults Living in Long-Term Care Facilities in the City of Cape Town.International journal of environmental research and public health · 2025Article
- Predictive Factors and the Predictive Scoring System for Falls in Acute Care Inpatients: Retrospective Cohort Study.JMIR human factors · 2025Article
- Post-surgical fall risk prediction: a machine learning approach for spine and lower extremity procedures.Frontiers in medicine · 2025Article
- The Administration of Lemborexant at Admission is Not Associated with Inpatient Falls: A Multicenter Retrospective Observational Study.International journal of general medicine · 2024Article
- Association between psychotropics use and occurrence of falls in hospitalized patients: A matched case-control study.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Article
- Potentially inappropriate medications and their effect on falls during hospital admission.Age and ageing · 2022Observational
- Mild cognitive impairment: associations with sleep disturbance, apolipoprotein e4, and sleep medications.Sleep medicine · 2018Article
- Safety of brotizolam in hospitalized patients.European journal of clinical pharmacology · 2018Article
- South Korean geriatrics on Beers Criteria medications at risk of adverse drug events.PloS one · 2018Article
- Sleeping Pill Administration Time and Patient Subjective Satisfaction.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- Hyponatremia and hypokalemia as risk factors for falls.European journal of clinical nutrition · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFalls and related injuries remain a concern for patient safety in many hospitals and nursing care facilities. In particular, reports examining the relationship between accidents and drugs with a sedative effect have been increasing; however, the analysis of correlation between the background factors of fall accidents and the detailed therapeutic category of drugs is insufficient.
objectivesOur objective was to estimate fall risk following the administration of hypnotics in inpatients within an acute hospital. We assessed the relationship between falls and hypnotic drugs compared with other medicines. STUDY DESIGN AND
settingAn inpatient population-based study was carried out at Gunma University Hospital, where all inpatients admitted between 1 October and 31 December 2007 were included. Over a 3-month follow-up period, all reports of falling accidents from ward medical staff were investigated. RESULTS AND DISCUSSION: Falls occurred in 1.8% of males and 1.3% of females in the study population (n = 3,683). The mean age of patients who experienced falls (64.7 ± 19.5 years) was significantly higher than that of patients who did not (56.2 ± 20.2 years). Multivariate analysis revealed the following drugs as high-risk factors for falling: hypnotics (odds ratio [OR] 2.17, 95% CI 1.44-3.28), antiepileptics (OR 5.06, 95% CI 2.70-9.46), opioids (OR 3.91, 95% CI 2.16-7.10), anti-Alzheimer's (OR 5.74, 95% CI 1.62-20.3), anti-Parkinson's (OR 5.06, 95% CI 1.58-16.24), antidiabetics (OR 3.08, 95% CI 1.63-5.84), antihypertensives (OR 2.24, 95% CI 1.41-3.56), and antiarrhythmics (OR 2.82, 95% CI 1.36-5.86). Multivariate logistic regression analysis of hypnotics, brotizolam, zopiclone, and estazolam revealed a significant association with an increased risk of inpatient falling accidents, while zolpidem, triazolam, flunitrazepam, and nitrazepam did not.
conclusionThe present findings suggest that the risk of falling accidents in hospitals differs according to the type of hypnotic drug administered. The appropriate selection of hypnotic drugs, therefore, might be important for reducing the number of patient falls.
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