ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Image characteristics of retained medullary cord in secondary neurulation arrest: an observational study.Scientific reports · 2024Observational
- Neural Tube Organoids: A Novel System to Study Developmental Timing.Stem cell reviews and reports · 2024Review
- Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.Development (Cambridge, England) · 2023Article
- Myelomeningocele as an anomaly of secondary neurulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Disorders of Secondary Neurulation: Suggestion of a New Classification According to Pathoembryogenesis.Advances and technical standards in neurosurgery · 2022Article
- Cystic retained medullary cord in an intraspinal J-shaped cul-de-sac: a lesion in the spectrum of regression failure during secondary neurulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Overview of Secondary Neurulation.Journal of Korean Neurosurgical Society · 2021Article
- Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development.Journal of Korean Neurosurgical Society · 2021Article
- Refractory CSF leakage following untethering surgery performed 10 months after birth for enlarging terminal myelocystocele associated with OEIS complex.Surgical neurology international · 2021Article
- Terminal Myelocystocele : Pathoembryogenesis and Clinical Features.Journal of Korean Neurosurgical Society · 2020Article
- Spinal Dysraphism in the Last Two Decades : What I Have Seen during the Era of Dynamic Advancement.Journal of Korean Neurosurgical Society · 2020Article
- Junctional neural tube defect in a newborn: report of a fourth case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
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9 authors at 4 institutions in 1 country.
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Abstract
purposeThe morphological changes and expression patterns of neuronal antigens of human embryos, obtained from the therapeutic termination of pregnancy or from surgical procedures, were analyzed in order to characterize the secondary neurulation.
methodsA total of 21 human embryos from Carnegie stages 12 to 23 and two fetuses in early stages were studied. The markers used for immunohistochemical study were neural cell adhesion molecule (N-CAM), neuronal nuclear antigen (NeuN), neurofilament-associated protein (3A10), synaptophysin, and glial fibrillary acidic protein (GFAP).
resultsThe formation of the caudal neural tube to the tip of the caudal portion of the embryo was finished at stage 17. The postcloacal gut had completely disappeared at stage 18, and multiple cavities of the caudal neural tube were clearly visible. The caudal portion of the neural tube showed findings suggestive of involution at stage 19. The expression patterns of neuronal antigens were as follows: N-CAM and NeuN showed immunoreactivity at the germinal layer of the spinal cord at stages 17 and 18. Neurofilament-associated protein (3A10) showed persistent immunoreactivity at the caudal cell mass and notochord during the observation period, along with the spinal cord, and the positive reactions were mainly located at the dorsal white matter at stage 17. Synaptophysin showed a weak positive reaction at the caudal cell mass and notochord at stages 13 and 14, evident by staining observed at the spinal cord at stages 15 and 16. There was no definite positive reaction for GFAP.
conclusionsThese characteristic patterns might be helpful for the understanding of human congenital anomalies involving secondary neurulation processes.
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