ArticleFrontiers in human neuroscience2013
Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.International journal of molecular sciences · 2024Review
- Cumulative Genetic Scores Interact with Maternal and Paternal Parenting in Predicting Parent-Adolescent Cohesion and Conflict.Journal of youth and adolescence · 2024Article
- Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It "Blowin' in the Wind"?Journal of personalized medicine · 2022Article
- Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress.Neuropharmacology · 2019Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum.Translational psychiatry · 2017Article
- Itopride for gastric volume, gastric emptying and drinking capacity in functional dyspepsia.World journal of gastrointestinal pharmacology and therapeutics · 2017Article
- Behavioral and Neural Manifestations of Reward Memory in Carriers of Low-Expressing versus High-Expressing Genetic Variants of the Dopamine D2 Receptor.Frontiers in psychology · 2017Article
- Gender-specific modulation of neural mechanisms underlying social reward processing by Autism Quotient.Social cognitive and affective neuroscience · 2015Article
- Article
- Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression.Frontiers in systems neuroscience · 2014Article
- Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory.Frontiers in human neuroscience · 2014Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards. This dual function of dopamine suggests that dopamine might be involved in the generation of active motivated behavior. The DRD2 TaqIA polymorphism of the dopamine D2 receptor gene (rs1800497) has previously been suggested to affect striatal function with carriers of the less common A1 allele exhibiting reduced striatal D2 receptor density and increased risk for addiction. Here we aimed to investigate the influences of DRD2 TaqIA genotype on the modulation of interference processing by reward and punishment. Forty-six young, healthy volunteers participated in a behavioral experiment, and 32 underwent functional magnetic resonance imaging (fMRI). Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both). Reaction times (RTs) were shorter in motivated flanker trials, irrespective of congruency. In the fMRI experiment motivation was associated with reduced prefrontal activation during incongruent vs. congruent flanker trials, possibly reflecting increased processing efficiency. DRD2 TaqIA genotype did not affect overall RTs, but interacted with motivation on the congruency-related RT differences, with A1 carriers showing smaller interference effects to reward alone and A2 homozygotes exhibiting a specific interference reduction during combined reward (REW) and punishment trials (PUN). In fMRI, anterior cingulate activity showed a similar pattern of genotype-related modulation. Additionally, A1 carriers showed increased anterior insula activation relative to A2 homozygotes. Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.