ArticleOpen biology2013
The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.
Article in Open biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Double, double toil and trouble: transforming growth factor beta (TGF-β) in HIV infection.Frontiers in immunology · 2025Review
- Article
- Pattern detection in the TGFβ cascade controls the induction of long-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3.The American journal of pathology · 2022Article
- Diversity and versatility of p38 kinase signalling in health and disease.Nature reviews. Molecular cell biology · 2021Review
- An important role of PHRF1 in dendritic architecture and memory formation by modulating TGF-β signaling.Scientific reports · 2020Article
- Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4.Journal of biomedical science · 2019Article
- A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability.International journal of molecular sciences · 2019Article
- Inferring Novel Tumor Suppressor Genes with a Protein-Protein Interaction Network and Network Diffusion Algorithms.Molecular therapy. Methods & clinical development · 2018Article
- Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis.Inflammopharmacology · 2018Article
- Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death.Genesis (New York, N.Y. : 2000) · 2018Article
- The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.Nature communications · 2017Article
- Targeting endogenous proteins for degradation through the affinity-directed protein missile system.Open biology · 2017Article
- Non-Smad Signaling Pathways of the TGF-β Family.Cold Spring Harbor perspectives in biology · 2017Review
- Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.Developmental biology · 2015Article
- Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).Journal of medicinal chemistry · 2015Article
- The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.Cellular signalling · 2014Review
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The signalling pathways downstream of the transforming growth factor beta (TGFβ) family of cytokines play critical roles in all aspects of cellular homeostasis. The phosphorylation and activation of p38 mitogen-activated protein kinase (MAPK) has been implicated in TGFβ-induced epithelial-to-mesenchymal transition and apoptosis. The precise molecular mechanisms by which TGFβ cytokines induce the phosphorylation and activation of p38 MAPK are unclear. In this study, I demonstrate that TGFβ-activated kinase 1 (TAK1/MAP3K7) does not play a role in the TGFβ-induced phosphorylation and activation of p38 MAPK in MEFs and HaCaT keratinocytes. Instead, RNAi-mediated depletion of MAP3K4 and MAP3K10 results in the inhibition of the TGFβ-induced p38 MAPK phosphorylation. Furthermore, the depletion of MAP3K10 from cells homozygously knocked-in with a catalytically inactive mutant of MAP3K4 completely abolishes the TGFβ-induced phosphorylation of p38 MAPK, implying that among MAP3Ks, MAP3K4 and MAP3K10 are sufficient for mediating the TGFβ-induced activation of p38 MAPK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.